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EC number: 200-773-6
CAS number: 72-18-4
L-valine did not show any acute toxicity effects to fish in a GLP
guideline study according to OECD 203. Both LC50 and LC100 > 10 g/L,
NOEC (mortality; condition) >= 10 g/L.
L-valine did not cause mortality in a GLP guideline study according to
OECD 202 up to the maximum test concentration of 10 g/l. EC100 (mobilty)
was > 10 g/l. NOEC (mobility) was estimated to be < 10 g/l and NOEC
(condition) was estimated to be 3.2 g/l.
L-valine did not show toxicity to microorganisms in a test according to
(draft) DIN 38 412, L8 with the test organism Pseudomonas putida. The EC
10 after 16 h was > 9.9 g/kg.
EC50 for algae was calculated to be ca. 2651 mg/L.
Considering the results from higher trophic levels and for
microorganisms, read across from L-alanine and an expert statement (see
endpoint summary in IUCLID section 6.1.5) toxicity testing with aquatic
algae was not deemed necessary.
The results do not trigger classification.
In respect of REACH Art. 14 in conjunction with REACH Annex I a CSA is
required which includes an exposure assessment if the particular
substance fulfils the criteria for any of most hazard classes or
categories set out in Annex I to regulation 1272/2008 or is assessed to
be a PBT / vPvB (for details see REACH Annex I, Section 0.6.3.). Annex
I, Section 5.0 of the REACH Regulation states that the exposure
assessment “shall cover any exposures that may relate to the hazards
identified in Sections 1 to 4”.
Thus REACH requires that the exposure assessment is closely linked to
the hazard assessment, which may identify hazards either for the
environment, or for human health, or for both. The hazard assessment
(including the classification) as well as the performance of an exposure
assessment are focused either on possible effects on the environment or
on possible effects on human health. Thus, any substance of a nature
identified as hazardous to human health (and a respective
classification) triggers an assessment of the exposure of humans, but
not of the environment. L-valine does not fulfil the criteria relating
to environmental hazards (wording of EU-GHS, in particular Art. 3). Thus
an exposure assessment within the Chemical Safety Assessment for
L-valine is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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