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EC number: 932-121-8 | CAS number: 1147459-12-8
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
No effect were observed at the highest concentration tested (1000 mg/kg soil dry weight corresponding to 910 mg a.i./kg soil dry weight).
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 910 mg/kg soil dw
Additional information
Eisenia fetida were exposed to Amides, C18-unsatd., N-[3-(dimethylamine)propyl] according to OECD Guideline 222 and GLP requirements. A range of concentrations composing of 0, 62.5, 125, 250, 500 and 1000 mg/kg soil dry weight corresponding to 56.9, 113.8, 227.5, 455 and 910 mg a.i./kg soil dry weight was used. The adult worms were between 8 and 9 months old and were exposed to the test substance for 56 days. The substrate used was artifical soil. There were 6 treatment groups with 4 replicates for the test item treatments and 8 replicates for the control with 10 worms each. The worms were assessed for adult worm mortality, behavioural effects and biomass development after 28 days of exposure. The reproduction rate was assessed after an additional 28 days.
All study validity criteria were met. No mortality was observed in any treatment group. The body weight change of the earthworms after 4 weeks exposure was not statistically significant different compared to the control up to and including the highest test concentration of 1000 mg test item/kg soil dry weight (Dunnett's test,α = 0.05). The reproduction rates after 8 weeks exposure to Amides, C18-unsatd., N-[3-(dimethylamine)propyl] were not significantly different compared to the control up to and including the highest test concentration of 1000 mg test item/kg soil ( Dunnett's t-test,α = 0.05). No behavioural abnormalities were observed in any of the treatment groups.
It is considered justified to use this test result as obtained for Amides, C18-unsatd., N-[3-(dimethylamine)propyl] for read-across to N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide because a similar toxicity is anticipated for organisms living in the terrestrial compartments. Indeed, the main exposure route for sorbing substances is via ingestion (comber 2008) and the limited expected difference in sorption to soil for a certain soil type because the main driver in the sorption of such substances is ionic interaction.
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