Registration Dossier
Registration Dossier
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EC number: 932-121-8 | CAS number: 1147459-12-8
Endpoint summary
Administrative data
Description of key information
Additional information
N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide (=cocoamidopropyl dimethylamine) is protonated under environmental conditions. This means that they will sorb strongly to negatively charged substances like glassware, soil and sediment constituents. For three different soils Kd values were observed ranging from: 2500 to 4500 L/kg.
Ready biodegradability of cocoamidopropyl dimethylamine has been demonstrated in the OECD 301 D “Ready biodegradability - Closed Bottle Test” (Van Ginkel, 2009). The percentage of biodegradation of 2 mg/L of test substance reached 85 % after 28 days and thus cocoamidopropyl dimethylamine was considered as readily biodegradable.
Biodegradation is therefore considered to be the main removal mechanism of this substance. The half-life in the different environmental compartments is expected to be short. No data is however available for the determination of the half-life of cocoamidopropyl dimethylamine in soil or sediment. These values are therefore estimated as a worst-case based on the readily biodegradability of the available fraction and the sorption data as determined in a sorption desorption test. In addition, these results as observed for cocoamidopropyl dimethylamine can be considered to represent the worst-case removal for cocoamidopropyl dimethylamine. Indeed, a higher total removal and lower removal via sorption are anticipated for cocoamidopropyl dimethylamine.
Standard OECD 305 tests to assess the bioaccumulation are technically not feasible with these strongly sorbing easily degradable substances. Furthermore, the route of exposure is unrealistic for these substances because the substance will either be sorbed or biodegraded.
A BCF value has therefore been calculated using the BCFBAF module in EPIWEB 4.1. The half-lives as used in this model are in good agreement with the half-lives observed in the in-vitro biotransformation tests performed with cocoamidopropyl dimethylamine. Using this model a BCF of 33.7 L/kg is calculated.
Based on the rapid biotransformation in fish and ready biodegradability of the substanceit is very unlikely that cocoamidopropyl dimethylamine will accumulate in the food chain.
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