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EC number: 300-202-1 | CAS number: 93924-10-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- specific investigations: other studies
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- other: absorption of carbon-14 radiolabelled alpha-olefin
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, Bicester, UK.
- Age at study initiation: 9 weeks
- Weight at study initiation: na
- Fasting period before study:
- Housing: sawdust in solid-bottom, polypropylene cages. Bedding was changed once weekly.
- Diet (e.g. ad libitum): RM1 powdered diet (Special Diet Services Ltd., Stepfield, Witham, Essex, UK) was used. Diet was provided ad libitum prior to and throughout the Study.
- Water (e.g. ad libitum): local supply and provided in bottles, ad libitum prior to and throughout the study
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23° C
- Humidity (%): 40-70%
- Air changes (per hr): 14-15 air changes per hour
- Photoperiod (hrs dark / hrs light): Twelve-hour periods of light were cycled with twelve-hour periods of darkness
IN-LIFE DATES: From: To: - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- Dosing solutions and dosing
The test material was formulated in corn oil as follows:
190µL of unlabelled alpha-olefin + 10µL of 14C-alpha olefin were added to 19.8mL of corn oil to provide a dosing solution of approximately 10µCi/100mg.
A single oral gavage of 100mg alpha olefin/kg bodyweight with a dosing volume of 10mL/kg bodyweight was given to each rat on the day of dosing. - Frequency of treatment:
- single dose exposure
- Post exposure period:
- Urine and faeces collection and terminal samples
Urine and faeces samples were collected on dry-ice at 24 hour intervals after dosing for up to 96 hours.
On day four after dosing the animals were transferred to the post mortem room for termination.
Blood, liver, adipose and kidney samples were collected at termination and stored at -20°C for further investigation. - Details on study design:
- Animals Rats in group 1 only, 1-Octene were housed in glass metabolism cages 24 hours prior to dosing and control faeces and urine were collected. Groups 2, 3 were housed in glass metabolism cages on day of dosing.
- Examinations:
- Urine samples, faeces samples, terminal blood samples, tissue samples (liver, kidney and adipose)
- Details on results:
- The total amount of radioactivity administered to each animal was calculated using the volume of dosing solution administered by oral gavage.
- Conclusions:
- The radioactivity of 1-decene was rapidly excreted into the urine and faeces and most of recovered radiolabeled material was recorded in the first 48 hours after dosing. Low amount of radioacivity recovery was detected in urine, faeces, whole body terminal blood, liver, kidney and adipose tissue was 17%.
- Executive summary:
The results of the study conducted on 1 -decene showed that radioactivity was rapidly excreted into the urine and faeces and most of recovered radiolabeled material in the urine and faeces was recorded in the first 48 hours after dosing. Low amount of radioacivity recovery was detected in urine, faeces, whole body terminal blood, liver, kidney and adipose tissue for 17%.
The low recoveries of radioactivity might be explained with oxidative metabolism of the olefins to metabolites which may be metabolised to acetate and acetone, and then converted to CO2 which is exhaled. Another hypotheses is the direct exhalation of the parent olefins from the lungs to a rapid volatilisation of the chemicals from the aqueous environment of the alveoli at a rapid rate.
Table 1. Total radioactivity dosed to each animal
Group |
Rat Number |
Dosing volume administered (mL) |
Total radioactivity dosed (dpm) |
|
|||
1-Decene |
5 |
2.3 |
4308652.1 |
6 |
2.3 |
4308652.1 |
|
7 |
2.4 |
4495984.8 |
|
8 |
2.3 |
4308652.1 |
|
dpm = disintegrations per minute
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- other: absorption of carbon-14 radiolabelled alpha-olefin
Test material
- Reference substance name:
- 1-decene
- IUPAC Name:
- 1-decene
- Reference substance name:
- Dec-1-ene
- EC Number:
- 212-819-2
- EC Name:
- Dec-1-ene
- Cas Number:
- 872-05-9
- Molecular formula:
- C10H20
- IUPAC Name:
- dec-1-ene
- Details on test material:
- Radiolabelled Test material : Carbon-14 labelled alpha-olefin 1-Decene (CAS No. 872-05-9)
Unlabelled Test material: Decene (CAS No. 872-05-9)
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, Bicester, UK.
- Age at study initiation: 9 weeks
- Weight at study initiation: na
- Fasting period before study:
- Housing: sawdust in solid-bottom, polypropylene cages. Bedding was changed once weekly.
- Diet (e.g. ad libitum): RM1 powdered diet (Special Diet Services Ltd., Stepfield, Witham, Essex, UK) was used. Diet was provided ad libitum prior to and throughout the Study.
- Water (e.g. ad libitum): local supply and provided in bottles, ad libitum prior to and throughout the study
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23° C
- Humidity (%): 40-70%
- Air changes (per hr): 14-15 air changes per hour
- Photoperiod (hrs dark / hrs light): Twelve-hour periods of light were cycled with twelve-hour periods of darkness
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- Dosing solutions and dosing
The test material was formulated in corn oil as follows:
190µL of unlabelled alpha-olefin + 10µL of 14C-alpha olefin were added to 19.8mL of corn oil to provide a dosing solution of approximately 10µCi/100mg.
A single oral gavage of 100mg alpha olefin/kg bodyweight with a dosing volume of 10mL/kg bodyweight was given to each rat on the day of dosing. - Frequency of treatment:
- single dose exposure
- Post exposure period:
- Urine and faeces collection and terminal samples
Urine and faeces samples were collected on dry-ice at 24 hour intervals after dosing for up to 96 hours.
On day four after dosing the animals were transferred to the post mortem room for termination.
Blood, liver, adipose and kidney samples were collected at termination and stored at -20°C for further investigation.
- Details on study design:
- Animals Rats in group 1 only, 1-Octene were housed in glass metabolism cages 24 hours prior to dosing and control faeces and urine were collected. Groups 2, 3 were housed in glass metabolism cages on day of dosing.
Examinations
- Examinations:
- Urine samples, faeces samples, terminal blood samples, tissue samples (liver, kidney and adipose)
Results and discussion
- Details on results:
- The total amount of radioactivity administered to each animal was calculated using the volume of dosing solution administered by oral gavage.
Any other information on results incl. tables
Table 1. Total radioactivity dosed to each animal
Group |
Rat Number |
Dosing volume administered (mL) |
Total radioactivity dosed (dpm) |
|
|||
1-Decene |
5 |
2.3 |
4308652.1 |
6 |
2.3 |
4308652.1 |
|
7 |
2.4 |
4495984.8 |
|
8 |
2.3 |
4308652.1 |
|
dpm = disintegrations per minute
Applicant's summary and conclusion
- Conclusions:
- The radioactivity of 1-decene was rapidly excreted into the urine and faeces and most of recovered radiolabeled material was recorded in the first 48 hours after dosing. Low amount of radioacivity recovery was detected in urine, faeces, whole body terminal blood, liver, kidney and adipose tissue was 17%.
- Executive summary:
The results of the study conducted on 1 -decene showed that radioactivity was rapidly excreted into the urine and faeces and most of recovered radiolabeled material in the urine and faeces was recorded in the first 48 hours after dosing. Low amount of radioacivity recovery was detected in urine, faeces, whole body terminal blood, liver, kidney and adipose tissue for 17%.
The low recoveries of radioactivity might be explained with oxidative metabolism of the olefins to metabolites which may be metabolised to acetate and acetone, and then converted to CO2 which is exhaled. Another hypotheses is the direct exhalation of the parent olefins from the lungs to a rapid volatilisation of the chemicals from the aqueous environment of the alveoli at a rapid rate.
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