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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summary information only, very limited information is available for the interpretation of the results.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960

Materials and methods

Principles of method if other than guideline:
This study followed internal Dow procedures.
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)
EC Number:
205-381-9
EC Name:
Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)
Cas Number:
139-89-9
Molecular formula:
C10H18N2O7.3Na
IUPAC Name:
trisodium 2-({2-[bis(carboxymethyl)amino]ethyl}(2-hydroxyethyl)amino)acetate
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): N-hydroxyethyl ethylenediamine triacetic acid, trisodium salt (Versene powder)
- Molecular formula (if other than submission substance): C10H15O7N2Na3
- Molecular weight (if other than submission substance): 344.20
- Physical state: powder
- Color: White
- All other template details: Not reported

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not reported

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Not reported
Duration of exposure:
undiluted - intact skin - 10 applications to the belly
undiluted -abraded skin - 3 applications to the belly
10% aqueous solution - intact skin - 10 applications to the ear
10% aqueous solution - intact skin - 10 applications to the belly
10% aqueous solution - abraded skin - 3 applications to the belly
Doses:
undiluted and in a 10% aqueous solution
No. of animals per sex per dose:
Not reported
Control animals:
no
Details on study design:
- Conclusions based on the skin irritation/corrosion study
- Duration of observation period following administration: up to 21 days
- All other template details: not reported
Statistics:
Not reported

Results and discussion

Preliminary study:
There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
Mortality:
None reported
Clinical signs:
undiluted - intact skin - 10 applications to the belly: Slight hyperemia throughout experiment - slight edema persisted after 4th application.
undiluted -abraded skin - 3 applications to the belly: Slight to moderate hyperemia with slight edema after each application - moderate necrosis followed 3rd application - skin healed with slight scar in 21days.

10% aqueous solution - intact skin - 10 applications to the ear: Slight hyperemia after 3rd and 4th applications only.
10% aqueous solution - intact skin - 10 applications to the belly: Slight hyperemia after 2nd, 3rd and 4th applications only.
10% aqueous solution - abraded skin - 3 applications to the belly: Hyperemia during 1st 4 days of experiment only - skin essentially normal in 14 days.
Body weight:
Not reported
Gross pathology:
Not reported
Other findings:
Not reported

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Conclusions:
There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
Executive summary:

There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.