Registration Dossier
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EC number: 205-381-9 | CAS number: 139-89-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary information only, very limited information is available for the interpretation of the results.
Cross-reference
- Reason / purpose:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report Date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- This study followed internal Dow procedures.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): N-hydroxyethyl ethylenediamine triacetic acid, trisodium salt (Versene powder)
- Molecular formula (if other than submission substance): C10H15O7N2Na3
- Molecular weight (if other than submission substance): 344.20
- Physical state: powder
- Color: White
- All other template details: Not reported
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Not reported
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Not reported
- Duration of exposure:
- undiluted - intact skin - 10 applications to the belly
undiluted -abraded skin - 3 applications to the belly
10% aqueous solution - intact skin - 10 applications to the ear
10% aqueous solution - intact skin - 10 applications to the belly
10% aqueous solution - abraded skin - 3 applications to the belly - Doses:
- undiluted and in a 10% aqueous solution
- No. of animals per sex per dose:
- Not reported
- Control animals:
- no
- Details on study design:
- - Conclusions based on the skin irritation/corrosion study
- Duration of observation period following administration: up to 21 days
- All other template details: not reported - Statistics:
- Not reported
Results and discussion
- Preliminary study:
- There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
- Mortality:
- None reported
- Clinical signs:
- undiluted - intact skin - 10 applications to the belly: Slight hyperemia throughout experiment - slight edema persisted after 4th application.
undiluted -abraded skin - 3 applications to the belly: Slight to moderate hyperemia with slight edema after each application - moderate necrosis followed 3rd application - skin healed with slight scar in 21days.
10% aqueous solution - intact skin - 10 applications to the ear: Slight hyperemia after 3rd and 4th applications only.
10% aqueous solution - intact skin - 10 applications to the belly: Slight hyperemia after 2nd, 3rd and 4th applications only.
10% aqueous solution - abraded skin - 3 applications to the belly: Hyperemia during 1st 4 days of experiment only - skin essentially normal in 14 days. - Body weight:
- Not reported
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Conclusions:
- There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
- Executive summary:
There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
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