Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Summary information only, very limited information is available for the interpretation of the results.

Cross-reference

Reason / purpose:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Report Date:

1960

Materials and methods

Principles of method if other than guideline:

This study followed internal Dow procedures.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

solid: particulate/powder

Details on test material:

- Name of test material (as cited in study report): N-hydroxyethyl ethylenediamine triacetic acid, trisodium salt (Versene powder)
- Molecular formula (if other than submission substance): C10H15O7N2Na3
- Molecular weight (if other than submission substance): 344.20
- Physical state: powder
- Color: White
- All other template details: Not reported

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals and environmental conditions:

Not reported

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

Not reported

Duration of exposure:

undiluted - intact skin - 10 applications to the belly
undiluted -abraded skin - 3 applications to the belly
10% aqueous solution - intact skin - 10 applications to the ear
10% aqueous solution - intact skin - 10 applications to the belly
10% aqueous solution - abraded skin - 3 applications to the belly

Doses:

undiluted and in a 10% aqueous solution

No. of animals per sex per dose:

Not reported

Control animals:

no

Details on study design:

- Conclusions based on the skin irritation/corrosion study
- Duration of observation period following administration: up to 21 days
- All other template details: not reported

Statistics:

Not reported

Results and discussion

Preliminary study:

There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.

Mortality:

None reported

Clinical signs:

undiluted - intact skin - 10 applications to the belly: Slight hyperemia throughout experiment - slight edema persisted after 4th application.
undiluted -abraded skin - 3 applications to the belly: Slight to moderate hyperemia with slight edema after each application - moderate necrosis followed 3rd application - skin healed with slight scar in 21days.

10% aqueous solution - intact skin - 10 applications to the ear: Slight hyperemia after 3rd and 4th applications only.
10% aqueous solution - intact skin - 10 applications to the belly: Slight hyperemia after 2nd, 3rd and 4th applications only.
10% aqueous solution - abraded skin - 3 applications to the belly: Hyperemia during 1st 4 days of experiment only - skin essentially normal in 14 days.

Body weight:

Not reported

Gross pathology:

Not reported

Other findings:

Not reported

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Conclusions:

There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.

Executive summary:

There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.