Registration Dossier
Registration Dossier
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EC number: 907-131-0 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- cited in Final Report on the Safety Assessment of Triethylene Glycol and PEG-4 (2006).
- Author:
- McKennis et al.
- Year:
- 1 962
- Bibliographic source:
- International Journal of Toxicology 25 (2), 121 - 138
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- Principles of method if other than guideline:
- no information available about testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- 2 female rabbits were given single doses of 200 or 2000 mg/kg TEG on stomach tube. Urine from the dosed animals was subsequently collected for 24 hours.
- Duration and frequency of treatment / exposure:
- 24 hours
Doses / concentrationsopen allclose all
- Dose / conc.:
- 200 mg/kg bw (total dose)
- Remarks:
- Low dose rabbits
- Dose / conc.:
- 2 000 mg/kg bw (total dose)
- Remarks:
- High dose rabbits
- No. of animals per sex per dose / concentration:
- 2 female rabbits
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
Rabbits dosed with 200 or 2000 mg/kg TEG respectively excreted 34.3% or 28% of the dose amount as unchanged TEG. The urine of 1 rabbit contamined 35.2% of the administered dose as a hydroxyacid form of TEG.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: In discussing treatment of TEG poisoning, it was stated that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole. In discussing treatment of TEG poisoning, it was stated that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole or ethanol.
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