Registration Dossier
Registration Dossier
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EC number: 907-131-0 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Additional information is available in the endpoint summaries and the read-across justification (see section 13).
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Type:
- metabolism
- Results:
- Rat: Metabolism of the test substance by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole or ethanol.
- Type:
- excretion
- Results:
- Rat: The total recovery of radioactivity was 90.6% - 98.3% of the administered dose (86.1 - 90.0% in urine).
- Type:
- excretion
- Results:
- Rabbits: At 200 or 2000 mg/kg, respectively 34.3 and 28% of the test substance was excreted unchanged.
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No data are available for the test substance. McKennis (1962, cited in CIR 2006) stated, that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited, e.g. by 4-methylpyrazole or ethanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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