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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
Additional information is available in the endpoint summaries and the read-across justification (see section 13).
Reason / purpose:
read-across source
Reason / purpose:
read-across: supporting information
Reason / purpose:
read-across: supporting information
Key result
Duration:
30 min
Dose descriptor:
other: EC20
Effect conc.:
> 1 995 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: test result from RA Source CAS 111-46-6 (BASF, 1982)
Duration:
30 min
Dose descriptor:
EC10
Effect conc.:
> 1 995 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Remarks on result:
other: test result from RA Source CAS 112-27-6 (BASF, 1979)
Duration:
30 min
Dose descriptor:
other: EC20
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: test result from RA Source CAS 112-60-7 (BASF, 1979)

Description of key information

No inhibition of respiration is observed up to a concentration of 1995 mg/L. The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.

Key value for chemical safety assessment

Additional information

The assessment on the toxicity to microorganisms of the reaction mass of 2,2'-(ethylenedioxy)diethanol 3,6,9-trioxaundecane-1,11-diol is based on studies with the main components triethylene glycol (CAS 112-27-6) and tetraethylene glycol (CAS 112-60-7), and the close structural analogue diethylene glycol (CAS 111-46-6).

The toxicity of main component triethylene glycol to microorganisms was investigated in an industrial activated sludge respiration inhibition study (BASF, 1979). In this study activated industrial sludge was exposed to nominal test substance concentrations of 1.5, 300, 1995 mg/L for 30 min.Test concentrations were not analytically verified. The effects on microorganisms was determined by measuring total respiration rates and comparing these to an unexposed control. The test substance effected an increased respiration rate. The 30-min EC10 value was determined to be > 1995 mg/L.

Also, the toxicity of main component tetraethylene glycol to microorganisms was investigated in an industrial activated sludge respiration inhibition study (BASF, 1979). In this study domestic activated sludge was exposed to the test substance for 30 min. The test substance effected a promotion in respiration. The 30-min EC20 value was determined to be > 100 mg/L.

The toxicity of structural analogue diethylene glycol to microorganisms was investigated in a non-GLP industrial activated sludge respiration inhibition study (BASF, 1982) according to ISO 8192. In this study activated domestic sludge from municipal sewage treatment plant was exposed to nominal test substance concentrations of 15, 150, 750 and 1995 mg/L for 30 min. Test concentrations were not analytically verified. After 30 minutes, 0% promotion of respiration was observed in the 15, 150 mg/L treatments and 17% promotion of respiration was observed in the 750 and 1995 mg/L treatments. The 30-min EC20 value was determined to be > 1995 mg/L.

Overall, no inhibition of respiration is observed up to a conentration of 1995 mg/L.