Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent, an EC50 of 200 mg/L was determined in a study (Frazier, 1988 (American Cyanamid Co.)) performed with Daphnia magna. The substance is acutely not harmful to freshwater invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 200 mg/L
Additional information
No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied (please refer section 13 for the read across justification of the test substance). Based on the reported studies, which are consistent, an EC50 of 200 mg/L was determined in a key study (Frazier, 1988 (American Cyanamid Co.)) performed with Daphnia magna.
As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the source substance melamine CAS 108 -78-1 is justified. All effect values are minimum values as the molar ratio anion:cation equals 1.74.
In addition a supporting study was performed with Daphnia magna (Adema, 1978 (DSM)). In this study the acute toxicity of the compound, expressed as LC50 values, was low, the LC50 48 h being > 2000 mg melamine/L. The condition of the daphnids, however, was poor, even after this short exposure time with concentrations as low as 180 mg/L. The EC50 > 200 mg/L determined in Frazier, 1988 (American Cyanamid) was more reliable and therefore used as key value. In conclusion, the substance is acutely not harmful to aquatic invertebrates.
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