Registration Dossier
Registration Dossier
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EC number: 231-749-3 | CAS number: 7719-12-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study, detailed description of findings, non-standard test animal
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimentelle Studien ueber den Einfluß technisch und hygienisch wichtiger Gase und Daempfe auf den Organismus. Teil XII: Studien ueber Phosphortrichlorid
- Author:
- Butjagin PW
- Year:
- 1 904
- Bibliographic source:
- Arch Hygiene 49, 307-335
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute inhlation toxicity in cats; various expousre concentrations and times
- GLP compliance:
- no
- Remarks:
- : study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- Phosphorus trichloride
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 3 - <= 10 h
- Remarks on duration:
- various exposure periods were used
- Concentrations:
- 4-30, 40-330, 370-3870 ppm
(equivalent to 22.8-171, 228-1881, 2109- 22059 mg/m³) - No. of animals per sex per dose:
- 13
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
Symptoms:
At the low concentration, salivation, irregular respiration, dyspnoea, cough, lacrimation and sedation were observed. At the intermediate concentration, immediate agitation, reduced/irregular breathing, cough, sneezing, breathing through open mouth, foamy salivation, nasal discharge, rhinitis, conjunctivitis, dyspnoea and weightloss were apparent. At the high concentration, effects were comparable to those at the intermediate concentration, but were earlier in onset and more severe, Deaths also occurred in this group.
Necropsy:
low dose:
discoloration of nasal cavity, injection of trachea, lung
oedema, ecchymosis, medium dose: corneal opacity, conjunctivitis, nasal
corrosion, trachea contain foamy red liquid, oedema of epiglottis,
severe emphysema
high dose: as medium dose
Applicant's summary and conclusion
- Executive summary:
Acute inhlation exposure of cats to concentrations PCl3 for up to 10 hours resulted in a number of signs of toxicity, which were reported to be similar to those seen with HCl.
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