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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
not specified
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
yes
Details on sampling:
Concentrations were determined after 5 days for each of the 3 buffer systems using HPLC analysis.
Buffers:
- pH: 4.0
- Type and final molarity of buffer:
- Composition of buffer: citric acid: 0.056 M; sodium hydroxide: 0.068 M; sodium chloride: 0.044 M

- pH: 7.0
- Type and final molarity of buffer:
- Composition of buffer: potassium dihydrogen phosphate: 0.026 M; disodium hydrogen phosphate 0.041 M

- pH: 9.0
- Type and final molarity of buffer:
- Composition of buffer: sodium tetraborate: 0.013 M; hydrochloric acid 0.0046 M
Details on test conditions:
Buffer solutions containing the test substance were inclubated in the dark at 50 degrees celcius.
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.035 mol/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
0.035 mol/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
0.035 mol/L
Transformation products:
no
% Recovery:
> 99
St. dev.:
0.7
pH:
4
Temp.:
50 °C
Duration:
5 d
Remarks on result:
other: di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pent
% Recovery:
> 99
St. dev.:
0.7
pH:
7
Temp.:
50 °C
Duration:
5 d
Remarks on result:
other: di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pent
% Recovery:
> 99
St. dev.:
0.7
pH:
9
Temp.:
50 °C
Duration:
5 d
Remarks on result:
other: di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pent
Key result
Remarks on result:
not measured/tested
Remarks:
Study from 1992.

Results suggested that no significant hyrolysis took place in any of the buffer systems.

Conclusions:
Original substance concentration changed by less than 1% after 5 days. Therefore, it is concluded that the test substance is not sensitive to pH dependant hydrolysis.
Executive summary:

A test was conducted according to OECD 111 to assess abiotic hydrolytic transformations of di-pentaerythritol in aquatic systems at pH values normally found in the environment (pH 4 – 9).


 


The rate of hydrolysis of the test substance as a function of pH and the identity or nature and rates of formation and decline of hydrolysis products will dictate the degree to which organisms may be exposed due to surface water emissions of the test substance.


 


Sterile aqueous buffer solutions of different pH values (pH 4, 7 and 9) were treated with the test substance and incubated in the dark under controlled laboratory conditions (at a constant temperature of 50oC). After the appropriate time interval (5 days), the buffer solutions were analysed for the test substance and for hydrolysis products. After 5 days, no significant transformation was observed. As such di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pentaerythritol will have a hydrolytic half life of greater than 1 year at envrionmentally relevant pH`s (4 -9) and temperatures.

Description of key information

Di-pentaerythritol is stable to hydrolysis at environmentally relevant pH ranges, i.e. half life of greater than 1 year.


 

Key value for chemical safety assessment

Additional information

A test was conducted according to OECD 111 to assess abiotic hydrolytic transformations of di-pentaerythritol in aquatic systems at pH values normally found in the environment (pH 4 – 9). After 5 days, no significant transformation was observed. As such di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the environment. It is therefore estimated that di-pentaerythritol will have a hydrolytic half life of greater than 1 year at environmentally relevant pH`s (4 -9) and temperatures (20 °C).

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