2,2,2',2'-tetrakis(hydroxymethyl)-3,3'-oxydipropan-1-ol

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

not specified

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

yes

Details on sampling:

Concentrations were determined after 5 days for each of the 3 buffer systems using HPLC analysis.

Buffers:

- pH: 4.0
- Type and final molarity of buffer:
- Composition of buffer: citric acid: 0.056 M; sodium hydroxide: 0.068 M; sodium chloride: 0.044 M

- pH: 7.0
- Type and final molarity of buffer:
- Composition of buffer: potassium dihydrogen phosphate: 0.026 M; disodium hydrogen phosphate 0.041 M

- pH: 9.0
- Type and final molarity of buffer:
- Composition of buffer: sodium tetraborate: 0.013 M; hydrochloric acid 0.0046 M

Details on test conditions:

Buffer solutions containing the test substance were inclubated in the dark at 50 degrees celcius.

Duration:

5 d

pH:

4

Temp.:

50 °C

Initial conc. measured:

0.035 mol/L

Duration:

5 d

pH:

7

Temp.:

50 °C

Initial conc. measured:

0.035 mol/L

Duration:

5 d

pH:

9

Temp.:

50 °C

Initial conc. measured:

0.035 mol/L

Transformation products:

no

% Recovery:

> 99

St. dev.:

0.7

pH:

4

Temp.:

50 °C

Duration:

5 d

Remarks on result:

other: di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pent

% Recovery:

> 99

St. dev.:

0.7

pH:

7

Temp.:

50 °C

Duration:

5 d

Remarks on result:

other: di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pent

% Recovery:

> 99

St. dev.:

0.7

pH:

9

Temp.:

50 °C

Duration:

5 d

Remarks on result:

other: di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pent

Key result

Remarks on result:

not measured/tested

Remarks:

Study from 1992.

Results suggested that no significant hyrolysis took place in any of the buffer systems.

Conclusions:

Original substance concentration changed by less than 1% after 5 days. Therefore, it is concluded that the test substance is not sensitive to pH dependant hydrolysis.

Executive summary:

A test was conducted according to OECD 111 to assess abiotic hydrolytic transformations of di-pentaerythritol in aquatic systems at pH values normally found in the environment (pH 4 – 9).

 

The rate of hydrolysis of the test substance as a function of pH and the identity or nature and rates of formation and decline of hydrolysis products will dictate the degree to which organisms may be exposed due to surface water emissions of the test substance.

 

Sterile aqueous buffer solutions of different pH values (pH 4, 7 and 9) were treated with the test substance and incubated in the dark under controlled laboratory conditions (at a constant temperature of 50oC). After the appropriate time interval (5 days), the buffer solutions were analysed for the test substance and for hydrolysis products. After 5 days, no significant transformation was observed. As such di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the envrionment. This study result indicates that di-pentaerythritol will have a hydrolytic half life of greater than 1 year at envrionmentally relevant pH`s (4 -9) and temperatures.

Description of key information

Di-pentaerythritol is stable to hydrolysis at environmentally relevant pH ranges, i.e. half life of greater than 1 year.

Additional information

A test was conducted according to OECD 111 to assess abiotic hydrolytic transformations of di-pentaerythritol in aquatic systems at pH values normally found in the environment (pH 4 – 9). After 5 days, no significant transformation was observed. As such di-pentaerythritol cannot be considered to be rapidly hydrolysed and the results suggest that abiotic removal by hydrolysis will not be an important pathway of degradation for di-pentaerythritol in the environment. It is therefore estimated that di-pentaerythritol will have a hydrolytic half life of greater than 1 year at environmentally relevant pH`s (4 -9) and temperatures (20 °C).