Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Epidemiological data

Currently viewing:

Administrative data

Endpoint:
epidemiological data
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Absence of control group, incomplete description of exposure and possibility for healthy worker effect severely restrict extrapolation

Data source

Reference
Reference Type:
publication
Title:
Health effects of long term exposure to sodium sulfate dust.
Author:
Kelada, F. and Euinton, L.E.
Year:
1978
Bibliographic source:
J. Occup. Med. 20(12):812-814.

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium sulphate
EC Number:
231-820-9
EC Name:
Sodium sulphate
Cas Number:
7757-82-6
Molecular formula:
H2O4S.2Na
IUPAC Name:
disodium sulfate

Results and discussion

Any other information on results incl. tables

RS-Freetext:
General medical screening, lung function tests, blood
pressure, skin condition, gastro-intestinal functioning,
serum sodium, calcium, potassium chloride and sulfate
content were all within normal ranges ( i.e presumably as
found in the general population). 

Mean urinary excretion of inorganic sulfate exceeded 2.2
gr/liter in all workers and thirty percent of the workers
excreted more than 3 gr of inorganic sulfate per day,
indicating massive uptake from recent exposure. The only
subjective symptom indicated by the workers was nasal
irritation and runny noses on exposure to dust. 

Internal sub-cohort study:
Short exposure duration subcohort: 
subjects: More than 10 years of exposure (n=77)
age 28.0 +-10, 
exposure duration 3.1  + 2.8 years 
Long exposure duration subcohort: 
Subjects: more than 10 years exposure (n=42) 
age 454.5 + 8.8, 
exposure duration 19.9 + 3.6 years 
Results: 
No differences other than explained by age difference.

Applicant's summary and conclusion