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Registration Dossier
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EC number: 921-577-3 | CAS number: 1174918-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There were no key skin sensitisation studies identified for hydrocarbons C5. Read-across skin sensitisation studies are available for n-pentane and 2 -methylbutane. For n-pentane, a study was conducted using guinea pigs (20 females/dose; 15 females for positive control; Trimmer, 1991). For the induction phase, six intradermal injections (0.1 mL each) were administered to three different sites as follows: Site 1: FCA/water to treated and control groups; Site 2: 5.0% n-pentane in carrier (ethanol) to the treated group, 100% ethanol to the control group; Site 3: 5.0% n-pentane in FCA/Water to the treated group, 5.0% carrier (reverse osmosis water) in FCA/Water to the control group. On day 7 following injection, 0.5 mL of a mild to moderately irritating dose of n-pentane was administered topically over the previously injected areas and covered with occlusive wrapping. Control animals received topical carrier applications instead. The challenge phase was conducted 21 days post induction phase. n-Pentane (0.1 mL of n-pentane; 1.0% in ethanol) was applied topically to the left flank of both treated and control irritation groups. All animals survived to study termination and displayed a weight gain from their day 0 values. Abnormal clinical observations during scheduled intervals were limited to one treated group animal that was emaciated and had a small amount of stool. Another animal exhibited slight emaciation and poor food consumption. Clinical signs observed in these two animals were considered to be correlated to the stress of the wrapping procedure and not treatment-related. No signs of dermal irritation were observed at any dose in either patch group. DNCB elicited positive reactions from all tested animals 24 and 48 hours after removal of the patch challenge. Based on the lack of signs dermal irritation observed in the study, n-pentane was not considered a dermal sensitiser.
For 2 -methylbutane, young adult Hartley albino guinea pigs (20 females per dose) were tested using the Guinea Pig Maximization Test method (Trimmer et al., 1991). Guinea pigs were exposed to the test material via induction twice to allow for development of sensitisation, then challenged and compared to the control group and examined for signs of dermal irritation. There was no evidence of dermal irritation or sensitisation in this study. 2-Methylbutane is not a dermal sensitizer.
Migrated from Short description of key information:
There were no key skin sensitisation studies identified for hydrocarbons C5. Read-across skin sensitisation studies are available for n-pentane (OECD 406) and 2-methylbutane (OECD 406 and EU Method B.6), in which the test substances were found not to be dermal sensitizers in guinea pigs.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Respiratory sensitisation is not a standard information requirement.
Migrated from Short description of key information:
No data identified.
Justification for classification or non-classification
Based on negative results from read-across skin sensitisation studies, hydrocarbons C5 is not considered to be a skin sensitizer and do not meet the criteria for classification as a dermal sensitizer under EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008. There are no data available for respiratory sensitisation for hydrocarbons C5 or the structural analogues.
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