Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 921-577-3
CAS number: -
were no key skin sensitisation studies identified for hydrocarbons C5. Read-across
skin sensitisation studies are available for n-pentane and 2
-methylbutane. For n-pentane, a study was conducted using guinea pigs
(20 females/dose; 15 females for positive control; Trimmer, 1991). For
the induction phase, six intradermal injections (0.1 mL each) were
administered to three different sites as follows: Site 1: FCA/water to
treated and control groups; Site 2: 5.0% n-pentane in carrier (ethanol)
to the treated group, 100% ethanol to the control group; Site 3: 5.0%
n-pentane in FCA/Water to the treated group, 5.0% carrier (reverse
osmosis water) in FCA/Water to the control group. On day 7 following
injection, 0.5 mL of a mild to moderately irritating dose of n-pentane
was administered topically over the previously injected areas and
covered with occlusive wrapping. Control animals received topical
carrier applications instead. The challenge phase was conducted 21 days
post induction phase. n-Pentane (0.1 mL of n-pentane; 1.0% in ethanol)
was applied topically to the left flank of both treated and control
irritation groups. All
animals survived to study termination and displayed a weight gain from
their day 0 values. Abnormal clinical observations during scheduled
intervals were limited to one treated group animal that was emaciated
and had a small amount of stool. Another animal exhibited slight
emaciation and poor food consumption. Clinical signs observed in these
two animals were considered to be correlated to the stress of the
wrapping procedure and not treatment-related. No signs of dermal
irritation were observed at any dose in either patch group. DNCB
elicited positive reactions from all tested animals 24 and 48 hours
after removal of the patch challenge. Based
on the lack of signs dermal irritation observed in the study, n-pentane
was not considered a dermal sensitiser.
2 -methylbutane, young adult Hartley albino guinea pigs (20 females per
dose) were tested using the Guinea Pig Maximization Test method (Trimmer
et al., 1991). Guinea pigs were exposed to the test material via
induction twice to allow for development of sensitisation, then
challenged and compared to the control group and examined for signs of
dermal irritation. There
was no evidence of dermal irritation or sensitisation in this study.
2-Methylbutane is not a dermal sensitizer.
sensitisation is not a standard information requirement.
Based on negative
results from read-across skin sensitisation studies, hydrocarbons C5 is
not considered to be a skin sensitizer and do not meet the criteria for
classification as a dermal sensitizer under EU Dangerous Substances
Directive 67/548/EEC or CLP EU Regulation 1272/2008. There are no data
available for respiratory sensitisation for hydrocarbons C5 or the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again