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EC number: 921-577-3 | CAS number: -
The number of animals used per compound per experiment is not reported. Abbreviated information on test methods and results was available because the study is a published article.
In a toxicokinetic study, F344 rats were exposed to a variety of hydrocarbon vapours, including 2 -methylbutane, via inhalation for 80 minutes for 5 consecutive days. Doses were as follows: 1 ppm on day 1; 10 ppm on day 2; 100 ppm on day 3; 1000 on day 4; and 5000 ppm on day 5. The study report only presents data for the 10 ppm dose.
When pentane was inhaled at 10 ppm, the uptake ranges were 1.6±0.2 and 1.5±0.2 nmol/kg/min/ppm (the mean of two experiments). Additionally, the uptake rate of pentane was greater than that of 2 methylbutane. The study authors concluded that (1) highly volatile hydrocarbons are less well-absorbed than less volatile hydrocarbons; (2) unsaturated compounds are better absorbed than saturated ones; and (3) branched hydrocarbons are less well-absorbed than unbranched ones.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because although the study did not follow an OECD guideline and it was not stated whether the study was GLP compliant, the study appears to be scientifically sound and there is an adequate level of detail.
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