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Short-term toxicity to aquatic invertebrates

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Description of key information

Cited from SIAR for SIAM 18 (Paris, France, April 20–23, 2004):
"The acute toxicity of 3-aminomethyl-3,5,5-trimethylcyclohexylamine to Daphnia magna was determined in a static test conducted according to OECD 202 (I) (1984). After 48 h of exposure, the EC50 was calculated to 23 mg/l (Infracor GmbH, 2002b). In a test according to DIN 38412, part 11 a nominal EC50 (24 h) of 44 mg/l was reported (Hüls AG, 1996a). The aquatic toxicity of 3-aminomethyl-3,5,5-trimethylcyclohexylamine was also tested in the marine invertebrate Chaetogammarus marinus. The 96 hour-EC50 determined in this semistatic test is 324 mg/l (Adema, 1982). However, despite of good test performance and documentation,the result with this non-standard organism may at present only serve as an indication that the sensitivity of marine invertebrates towards the test substance is probably not higher than that of freshwater organisms."

Key value for chemical safety assessment

Additional information

For the freshwater environment, the study on Daphnia magna conducted by Infracor GmbH, 2002 is considered as key study because it was conducted under GLP according to accepted scientific guidelines and shows the lowest toxicity endpoint. For the marine environment, the study reported by Adema, 1982 is taken into account, but it has to be noted that a non-standard test organism was used and that the test design was not in line with any accepted scientific guideline.

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