Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Isophorone diamine is not readily biodegradable (according to OECD criteria).

Additional information

Parent compound:

The biodegradation potential of IPDA was assessed in a DOC-Die Away Test performed according to EU method C.4-A (similar to OECD 301 A; Hüls AG, 1993, report no. DDA-02; reported in OECD SIDS 2004). As inoculum activated sludge from a biological treatment plant receiving primarily municipal sewage was used. The degradation was determined to be 8 % after 28 days (based on DOC removal).

This result is supported by a modified screening test performed according to OECD-Guideline 301 E (Ciba-Geigy Ltd., 1989, report no. 894015). A mixture of polyvalent bacteria collected as secondary effluent from a municipal treatment plant was used as inoculum. Biodegradation of IPDA was determined to be 15 % (DOC) after 28 days.  

In addition, the available experimental biodegradation data were supported by (Q)SAR calculations; the substance was within the applicability domain of both of the applied estimation models (BASF SE 2016):

- The model BIOWIN v4.10 implemented in the calculation platform EPISuite v4.11 predicted the substance to be not readily biodegradable. Furthermore, both of the submodels BIOWIN 2 (non-linear model prediction) and BIOWIN 6 (MITI non-linear model prediction) predicted the substance to not biodegrade fast.

- The model CATALOGIC 301C v09.13 (OASIS Catalogic v5.11.19) calculated biodegradation of IPDA to be 15% after 28 days, based on CO2-Evolution.

 

Metabolites:

In addition, the model CATALOGIC 301C v09.13 (OASIS Catalogic v5.11.19) predicted 112 metabolites, identifying 40 metabolites as relevant degradation products in terms of PBT/vPvB assessment, with an estimated quantity of ≥ 0.1% (for details see ‘Attached background material’ of the respective Endpoint Study Record).

36 of the 40 metabolites identified as relevant degradation products were calculated to be not readily biodegradable (between 0% and 41% after 28 days, based on BOD).

Only four metabolites were estimated to be readily biodegradable (between 66% and 89% after 28 days, based on BOD). In conclusion, the majority (90%) of the predicted metabolites present in concentration of ≥ 0.1% are estimated to be not readily biodegradable.

 

Conclusion:

Summing up the available experimental and calculated data, IPDA (CAS 2855-13-2) is concluded to be not readily biodegradable (according to OECD criteria).