Registration Dossier
Registration Dossier
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EC number: 202-429-0 | CAS number: 95-53-4
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Barlow SM, Sullivan FM (1982). Reproductive Hazards of Industrial Chemicals: 553-555
- Title:
- No information
- Author:
- Shabad LM (1969) Transplacentare Wirkung von blastomogenen Substanzen. Arzneim Forsch 19: 1044-1046
Materials and methods
- Principles of method if other than guideline:
- Method: other: see freetect ME
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: o-toluidine, no data on purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- whole period of gestation
- Frequency of treatment:
- every 4-5 days
- Details on study design:
- Sex: female
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Migrated dataset RS-Freetext:
o-toluidine induced hyperplasie in lungs and kidney explantates 3-4 days after explantation
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
