Registration Dossier

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Referenceopen allclose all

Title:
No information
Author:
Barlow SM, Sullivan FM (1982). Reproductive Hazards of Industrial Chemicals: 553-555
Title:
No information
Author:
Shabad LM (1969) Transplacentare Wirkung von blastomogenen Substanzen. Arzneim Forsch 19: 1044-1046

Materials and methods

Principles of method if other than guideline:
Method: other: see freetect ME
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
IUCLID4 Test substance: other TS: o-toluidine, no data on purity

Test animals

Species:
mouse
Strain:
Balb/c

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
whole period of gestation
Frequency of treatment:
every 4-5 days
Details on study design:
Sex: female

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

Migrated dataset
RS-Freetext:
o-toluidine induced hyperplasie in lungs and kidney explantates 3-4 days after explantation

Applicant's summary and conclusion