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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Reference
Title:
No information
Author:
Morigami S, Nisimura I (1940) Experimental studies on aniline bladder tumors. Gann Jpn J Cancer Res 34, 146-147; cited Toxikolog.-arbeitsmed. Begruendung von MAK-Werten, VCH|(1986)

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
o-toluidine
EC Number:
202-429-0
EC Name:
o-toluidine
Cas Number:
95-53-4
Molecular formula:
C7H9N
IUPAC Name:
2-methylaniline
Details on test material:
IUCLID4 Test substance: other TS: o-toluidine, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
no data
Frequency of treatment:
every second day
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 % solution in chloroform
Basis:

Control animals:
other: no data specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
In the advanced stages (time not specified) massive bladder haemorrhage was found together with vacuolization of the bladder epithelial cells. In many cases there was papilliferous proliferation of the epithelial cells into the lumen.

Applicant's summary and conclusion