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Registration Dossier
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EC number: 202-429-0 | CAS number: 95-53-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (few informations, investigated for dose finding only)
Data source
Reference
- Reference Type:
- publication
- Title:
- Vergleichende Kanzerogenese Versuche mit 2,4-Toluylendiamin, 2,4/2,6-Toluylendianin 80/20, m-Phenylendiamin, o-Toluidin, p-Toluidin, 4,4'-Diaminodiphenylnethan, Benzidin, bei subkutaner Applikation an Ratten
- Author:
- Bayer AG, Steinhoff D, Dycka
- Year:
- 1 981
- Bibliographic source:
- Unpublished report No 10682, July 06, 1981
Materials and methods
- Principles of method if other than guideline:
- dose finding for a cancerogenicity study
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- Molecular formula:
- C7H9N
- IUPAC Name:
- 2-methylaniline
- Details on test material:
- - Name of test material (as cited in study report): o-toludine
- Analytical purity: > 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- peanut oil
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 115 mg/kg bw
- 95% CL:
- 984 - 1 295
Applicant's summary and conclusion
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