Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (few informations, investigated for dose finding only)

Data source

Reference
Reference Type:
publication
Title:
Vergleichende Kanzerogenese Versuche mit 2,4-Toluylendiamin, 2,4/2,6-Toluylendianin 80/20, m-Phenylendiamin, o-Toluidin, p-Toluidin, 4,4'-Diaminodiphenylnethan, Benzidin, bei subkutaner Applikation an Ratten
Author:
Bayer AG, Steinhoff D, Dycka
Year:
1981
Bibliographic source:
Unpublished report No 10682, July 06, 1981

Materials and methods

Principles of method if other than guideline:
dose finding for a cancerogenicity study
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study

Test material

Constituent 1
Chemical structure
Reference substance name:
o-toluidine
EC Number:
202-429-0
EC Name:
o-toluidine
Cas Number:
95-53-4
Molecular formula:
C7H9N
IUPAC Name:
2-methylaniline
Details on test material:
- Name of test material (as cited in study report): o-toludine
- Analytical purity: > 99%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
peanut oil

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
1 115 mg/kg bw
95% CL:
984 - 1 295

Applicant's summary and conclusion