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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: review
Adequacy of study:
supporting study
Reliability:
other: peer-reviewed publication
Rationale for reliability incl. deficiencies:
other: peer reviewed publication

Data source

Reference
Reference Type:
publication
Title:
o-TOLUIDINE CAS No: 95-53-4 SIDS Initial Assessment Report.
Author:
CICAD 1998 cited in OECD SIDS
Year:
2006
Bibliographic source:
UNEP Publications

Materials and methods

Type of study / information:
citation of a review
Endpoint addressed:
basic toxicokinetics

Test material

Constituent 1
Chemical structure
Reference substance name:
o-toluidine
EC Number:
202-429-0
EC Name:
o-toluidine
Cas Number:
95-53-4
Molecular formula:
C7H9N
IUPAC Name:
2-methylaniline
Test material form:
other: liquid

Results and discussion

Results:
Biological monitoring to assess human exposure to o-toluidine indicates that absorption may occur through inhalation and dermal contact;
however,quantitative information was not identified. o-toluidine bindes to hemoglobin. N-acetylated metabolites of o-toluidine are eliminated
in the urine.

Applicant's summary and conclusion