o-toluidine

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: although secondary citation there is reliable information

Data source

Reference

Reference Type:

publication

Title:

No information

Author:

Stark M (cited by Greim 1992)

Year:

1982

Bibliographic source:

Ther Mh. 6: 376; cited in Greim 1992, Deutsche Forschungsgemeinschaft (DFG) (1992) Occupational Toxicants, critical data evaluation for MAK values and classification of Carcinogens: o-toluidine and o-toluidine hydrochloride, Vol 3: 307-322

Materials and methods

Study type:

poisoning incident

Endpoint addressed:

acute toxicity: inhalation

Principles of method if other than guideline:

Migrated dataset

GLP compliance:

no

Remarks:

GLP was not mandatory at the time of then study

Test material

Test material information

Constituent 1

Reference substance name:

o-toluidine

EC Number:

202-429-0

EC Name:

o-toluidine

Cas Number:

95-53-4

Molecular formula:

C7H9N

IUPAC Name:

2-methylaniline

Method

Reason of exposure:

accidental

Results and discussion

Outcome of incidence:

A worker transferred toluidine from one open vessel to another and , in the process inhaled enough vapour to cause mild poisoning, lost consiousness and remained unconscious in toluidine-contaminated clothes until evening. The patient was cyanotic and exhaled high levels of toluidine. the next day he urinated only very painfully and the urine contained blood. The strangury reached its peak on day 5. On day 8 the urinary complains regressed but blood was detectable in the urine until day 10. Full recovery required 5 weeks.