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Diss Factsheets
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EC number: 231-135-5 | CAS number: 7440-25-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Depleted Uranium Health Effects: Transformation, Mutagenicity, and Carcinogenicity
- Author:
- Miller AC
- Year:
- 1 998
- Bibliographic source:
- AFRRI Special Publication 98-3: 11-13
- Reference Type:
- publication
- Title:
- Health Effects of Depleted Uranium Fragments
- Author:
- Armed Forces Radiobiology Research Institute
- Year:
- 1 998
- Bibliographic source:
- Livengood DR (ed) An Armed Forces Radiobiology Research Institute Workshop
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Studies with depleted uranium embedded animals were reviewed to help assess the risk for carcinogenesis and mutagenesis from depleted uranium embedded fragments. Animals with tantalum embedded fragments served as a control.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tantalum
- EC Number:
- 231-135-5
- EC Name:
- Tantalum
- Cas Number:
- 7440-25-7
- Molecular formula:
- Ta
- IUPAC Name:
- tantalum
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): tantalum implants
Constituent 1
Results and discussion
Any other information on results incl. tables
Studies with depleted uranium embedded animals demonstrated that increased tissue uranium content was associated with aberrant activation of several of the oncogenes and tumour suppressor genes associated with preneoplastic lesions and human carcinogenesis. Specific point mutations in these genes have also been identified. In contrast, tissues from animals with tantalum implants did not show this aberrant oncogene pattern. Oncoproteins and tumour suppressor proteins were also found in the serum of animals with depleted uranium pellets. These proteins were not detected in serum from animals implanted with tantalum.
Applicant's summary and conclusion
- Conclusions:
- Tissues from animals with tantalum implants did not show an aberrant oncogene pattern. Oncoproteins and tumour suppressor proteins were not detected in serum from animals implanted with tantalum.
- Executive summary:
Studies to help assess the risk for carcinogenesis and mutagenesis from depleted uranium embedded fragments were conducted, with tantalum serving as a control. The studies with depleted uranium embedded animals demonstrated that increased tissue uranium content was associated with aberrant activation of several of the oncogenes and tumour suppressor genes associated with preneoplastic lesions and human carcinogenesis. Specific point mutations in these genes were also identified. In contrast, tissues from animals with tantalum implants did not show this aberrant oncogene pattern. Oncoproteins and tumour suppressor proteins were also found in the serum of animals with depleted uranium pellets. These proteins were not detected in serum from animals implanted with tantalum.
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