Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
NOAEL
500 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
5 000 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Additional information

Prediction based on currently available data on category substances.  Results corrected for molecular weight differences. There is no data on the repeat dose toxicity of this substance. Sub-acute bridging studies are being carried out on a number of substances within the catgory to add confidence to reading across results between members of this category.

Justification for classification or non-classification

From the available data, there is no indication of the substance exhibiting repeat dose toxicity that would warrant classification for specific target organ toxicity by repeated dose.