Registration Dossier
Registration Dossier
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EC number: 500-012-0 | CAS number: 9004-77-7
Endpoint summary
Administrative data
Description of key information
Oral LD50 data in rats: 1 study on the registered substance, LD50 >2000 mg/kg
Dermal LD50 in rabbits >2000 mg/kg (on a compenant of the registered substance substance)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 540 mg/kg bw
Additional information
An acute oral toxicity study performed in rats on the registered substance, the acute oral LD50 ofwas determined to be greater than 2000 mg/kg/bw.
The vapour pressure for 2 -(2 -(2-butoxyethoxy)ethoxy)ethanol is so low that no exposure is likely via the inhalation route and therefore no hazard would be expected by the inhalation route , bearing in mind the low toxicity by other routes.
In an acute dermal toxicity in rabbits, an LD50 of 3540mg/kg was obtain for the similar substance 2 -(2 -(2-butoxyethoxy)ethoxy)ethanol. Exposure was under occluded conditions. Information available suggests the dose response curve is unusually shallow. The data suggests significant absorption potential through skin but that absorption is <100%.
Read across is justified since toxicity decreases with increasing molecular weight within a given alkyl homologous series so the lowest molecular weight major component of this substance, (2 -(2 -(2 -butoxyethoxy)ethoxy)ethanol, is likely to be the most toxic (or in this case the "least non-toxic") component and data from it can be considered as a conservative surrogate for the toxicity of the UVCB substance "Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy" as a whole, as is the case for dermal toxicity.
Justification for classification or non-classification
The LD50 by the dermal route and the oral route are greater than the cut off dose of 2000mg/kg and therefore classification is not required. No adverse effects are seen following inhalation exposure to saturated vapour concentrations and therefore no classification by this route is required.
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