Registration Dossier
Registration Dossier
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EC number: 500-012-0 | CAS number: 9004-77-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Activated sludge respiration inhibition studies (substance 2-(2-(2-butoxyethoxy)ethoxyethoxyethanol:
EC0>1995mg/l
IC50>5000mg/l
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 995 mg/L
Additional information
There is no data available for this substance per se. There is data available for the lowest molecular weight component of this substance, that is also usually present at a significant concentration. In a guideline activated sludge respiration inhibition test using 2-(2-(2-butoxyethoxy)ethoxy)ethanol, no effects were observed up to the maximum tested concentration of 1995mg/l. In a bacterial growth inhibition study using sewage micro-organisms, the IC50 was found to be greater than 5000mg/l. Neither study contains sufficient detail to be used soley as a key study and therefore a weight of evidence approach is used to fulfil the requirements for this end point. The key parameter is selected as the lowest of the two values available. This result can be considered as representative of the toxicity of the substance
"Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy" Based on other glycol ethers,
aquatic toxicity decreases with increasing molecular weight within a given alkyl homologous series. Therefore the most 'toxic' component is likely to be the one for which data is available and therefore data from the latter can be considered as a conservative surrogate for the substance "Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy" as a whole.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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