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Diss Factsheets

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions.
Author:
Verrett, M.J., Scott, W.F., Reynaldo, E.F., Alterman, E.K., and Thomas, C.A.
Year:
1980
Bibliographic source:
Toxicology and Applied Pharmacology

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Although no formal guideline followed, the study is an accepted peer reviewed report
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
DL-malic acid
EC Number:
210-514-9
EC Name:
DL-malic acid
Cas Number:
617-48-1
Molecular formula:
C4H6O5
IUPAC Name:
malic acid
Constituent 2
Reference substance name:
Hydroxy succinic acid
IUPAC Name:
Hydroxy succinic acid

Test animals

Species:
other: chick embryos

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
NOEL
Effect level:
> 10 other: mg/egg
Based on:
test mat.
Basis for effect level:
other: other:

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:no effects

Details on embryotoxic / teratogenic effects:
Non teratogenic to chick embryos at upto 10 mg/egg

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

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