DL-malic acid

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

secondary source

Title:

Toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions.

Author:

Verrett, M.J., Scott, W.F., Reynaldo, E.F., Alterman, E.K., and Thomas, C.A.

Year:

1980

Bibliographic source:

Toxicology and Applied Pharmacology

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Although no formal guideline followed, the study is an accepted peer reviewed report

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

DL-malic acid

EC Number:

210-514-9

EC Name:

DL-malic acid

Cas Number:

617-48-1

Molecular formula:

C4H6O5

IUPAC Name:

malic acid

Constituent 2

Reference substance name:

Hydroxy succinic acid

IUPAC Name:

Hydroxy succinic acid

Test animals

Species:

other: chick embryos

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:

NOEL

Effect level:

> 10 other: mg/egg

Based on:

test mat.

Basis for effect level:

other: other:

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects:no effects

Details on embryotoxic / teratogenic effects:
Non teratogenic to chick embryos at upto 10 mg/egg

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified