Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Malic acid and fumaric acid accur naturally in many foods and synthetic forms of these acids are considered suitable as food additives.
A 2 year chronic study gave a NOAEL of 600 mg/kg

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
600 mg/kg bw/day

Additional information

Justification for classification or non-classification