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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Fumarate is metabolised as part of the Krebbs Cycle to Malate by the addition of water in the presence of the enzyme fumarase. This is an essential part of metabolism.


Since it is very likely that fumaric acid will metabolise through malic acid in biological systems, toxicological properties of fumaric acid will reflect the properties of malic acid. 

Published work by the WHO has demonstrated that the synthetic DL Malic acid will metabolise in the same way as the natural L isomer.