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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Inadequate dosing regime.

Data source

Reference
Reference Type:
publication
Title:
Hepato-toxicity of nickel, sodium lauryl sulphate and their combination after repeated dermal application in guinea pigs.
Author:
Mathur, A.K., B.N. Gupta, A. Singh, S. Singh, R. Shanker, and S. Narang.
Year:
1991
Bibliographic source:
Journal of Environmental Science and Health. A26(8):1333-1343.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Nickel sulphate
EC Number:
232-104-9
EC Name:
Nickel sulphate
Cas Number:
7786-81-4
Molecular formula:
NiSO4
IUPAC Name:
nickel(2+) sulfate
Details on test material:
- Reported as: Nickel Sulfate Hexahydrate, 10101-97-0

Test animals

Species:
guinea pig
Strain:
other: Albino
Sex:
male

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
7 and 14 days
Frequency of treatment:
not reported
Doses / concentrations
Remarks:
Doses / Concentrations:
50 mg/kg Ni
Basis:

Control animals:
yes, concurrent vehicle

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

STUDY RATED BY AN INDEPENDENT REVIEWER.

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