Registration Dossier
Registration Dossier
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EC number: 233-071-3 | CAS number: 10028-18-9
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Inadequate dosing regime.
Data source
Reference
- Reference Type:
- publication
- Title:
- Hepato-toxicity of nickel, sodium lauryl sulphate and their combination after repeated dermal application in guinea pigs.
- Author:
- Mathur, A.K., B.N. Gupta, A. Singh, S. Singh, R. Shanker, and S. Narang.
- Year:
- 1 991
- Bibliographic source:
- Journal of Environmental Science and Health. A26(8):1333-1343.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Nickel sulphate
- EC Number:
- 232-104-9
- EC Name:
- Nickel sulphate
- Cas Number:
- 7786-81-4
- Molecular formula:
- NiSO4
- IUPAC Name:
- nickel(2+) sulfate
- Details on test material:
- - Reported as: Nickel Sulfate Hexahydrate, 10101-97-0
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: Albino
- Sex:
- male
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 7 and 14 days
- Frequency of treatment:
- not reported
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 mg/kg Ni
Basis:
- Control animals:
- yes, concurrent vehicle
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
STUDY RATED BY AN INDEPENDENT REVIEWER.
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