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EC number: 233-071-3 | CAS number: 10028-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 26,2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not GLP - not enough details on test material
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Internale Guideline from Nipera
- Deviations:
- not specified
- Principles of method if other than guideline:
- 1) SIMULATED GASTRIC FLUID
Each extraction was performed using 0.1 gram of sample in 50 ml of Simulated Gastric Fluid (pH≤1.5). Samples were weighed into acid washed 250 ml amber Erlenmeyer flasks. Gastric Fluid was added to pH was checked for each solution and adjusted if necessary with 2N HCl.The flasks were covered with parafilm and aluminium foil.The flasks were paklced in a preheated 37°C reciprocal shaker bath.The samples were allowed toshake for the required exctraction times.Once complete, the solutions were removed from the bath.The pH was checked and solution were filtered trough a 0.45 µm filter. The filtrated were collected in 8 oz. disposable plastic bottle and kept in a 35°c incubator until analyzed by EPA method #200.8 (ICP/MS).
2)SIMULATED ALVEOLAR FLUID
Each extraction was performed using 0.1 gram of sample in 50 ml of Simulated Alveolar fluid (pH=7.4 ± 0.2). Sample were weighed into acid washed 250 ml amber Erlenmeyer flasks. Simulated alveolar fluid was added to the flasks and they were then swirled to mix compound and fluid.The ph was checked for each solution and adjusted if necessary with 2N Hcl or 1N NaOH. To keep the exctaction pH at 7.4,5% CO2 in Nitrogen was bubbled and alloed to shake for the required extraction times.Once complete, the solutions were removed from the bath. The pH was checked and solutions were filtered trough a 0.45 µm filter. The filtrates were collected in 8 g disposable plastic bottles and kept in a 35°C incubator until analyzed.
3)Artificial Perspiration
Each extraction was performed using 0.1 gram of sample in 50 ml of Simulated Alveolar fluid (pH=6.5 ± 0.1). Sample were weighed into acid washed 250 ml amber Erlenmeyer flasks. Perspiration was added to the flasks and they were then swirled to mix compound and fluid.The opening of the flasks were covered with parafilm and aluminum foil.The flask were then placed in a preheated 37°C water bath. No shaking was performedOnce the extraction was complete, the solution were removed from bath. The pH was checked and solutions were filtered trough a 0.45 µm filter. The filtrates were collected in 8 oz. disposable plastic bottles and kept in a 35°C incubator until analyzed. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Nickel fluoride (32.18% Nickel)
- IUPAC Name:
- Nickel fluoride (32.18% Nickel)
- Details on test material:
- - Name of test material (as cited in study report):nickel fluoride N111B-PTL (32.18% Nickel)
As Nickel is 32.18% of the powder, it is assumed that the starting material is NiF2*4H2O
Constituent 1
- Radiolabelling:
- no
Results and discussion
Any other information on results incl. tables
Simulated Gastric fluid | |||
Extraction time | ug Nickel/ g Sample |
% Nickel/ g Sample |
% Nickel Release/ Nickel content |
2 hours | 262.77 | 26.3 | 81.7 |
267.090 (dup) | 26.7 | 83 | |
5 hours | 264.875 | 26.5 | 82.3 |
270.300 (dup) | 27 | 84 | |
24 hours | 261.53 | 26.1 | 81.3 |
271.390 (dup) | 27.1 | 84.3 | |
72 hours | 273.86 | 27.4 | 85.1 |
282.115 (dup) | 28.2 | 87.7 |
Simulated Alveolar fluid | ||||
Extraction time | ug Nickel/ g Sample |
% Nickel/ g Sample |
% Nickel Release/ Nickel content |
|
2 hours | 116.6 | 11.7 | 36.2 | |
117.100 (dup) | 11.7 | 36.4 | ||
5 hours | 115.31 | 11.5 | 35.8 | |
131.110 (dup) | 13.1 | 40.7 | ||
24 hours | 132.015 | 13.2 | 41 | |
129.950 (dup) | 13 | 40.4 | ||
72 hours | 134.76 | 13.5 | 41.9 | |
136.185(dup) | 13.6 | 42.3 |
Artificial Perspiration | |||
Extraction time | ug Nickel/ g Sample |
% Nickel/ g Sample |
% Nickel Release/ Nickel content |
2 hours | 305.97 | 30.6 | 95.1 |
2 hours | 316.535 (dup) | 31.7 | 98.4 |
5 hours | 304.695 | 30.5 | 94.7 |
5 hours | 313.545 (dup) | 31.4 | 97.4 |
24 hours | 312.62 | 31.2 | 97.2 |
24 hours | 311.220 (dup) | 31.1 | 96.7 |
72 hours | 320.895 | 32.1 | 99.7 |
72 hours | 318.27 | 31.8 | 98.9 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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