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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to other aquatic organisms

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Link to relevant study record(s)

Description of key information

Many high quality studies are available in the database of toxicity to other aquatic vertebrates. A lumped data set for nickel-based compounds was considered for endpoint coverage. 

The lowest EC50 is 0.146 mg Ni/L for Xenopus laevis (Hopfer et al., 1991) and the highest EC50 is 3.740 mg Ni/L for Bufo terrestris (Fort et al., 2006). The LC50 values range from 0.420 mg Ni/L for Ambystoma opacum (Birge et al., 1978) to 21.42 mg Ni/L for Ambystoma opacum (Hopfer et al, 1991).

Additional information

Toxicity to Amphibians:

NOEC/L(E)C10 data are available for three species of amphibians, with values ranging from 84.5 µg Ni/L to 13.147 µg Ni/L, both values from Xenopus laevis (Hopfer et al., 1991).

The following table indicates those NOEC or EC10 values of high quality that have been carried forward for the HC5 & PNEC derivation.


  Key Study

(freshwater amphibians)

Selected values for the most sensitive endpoints used for derivation of the freshwater HC5




Value (ug/L) Ni


Hopfer et al., 1991

Xenopus laevis




Fort et al., 2004

Xenopus laevis




Bufo terrestris




Gastrophryne carolensis