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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

A lumped data set for nickel-based compounds was considered to conclude on the bioaccumulative properties of nickel. A BCF of 270 L Ni/kg was considered as key value for aquatic organisms (except for C.edule, for which a BCF of 1631 L Ni/kg was determined). For soil exposure, a BAF for earthworms of 0.3 was considered as key value.

Additional information

Though nickel does bioaccumulate in aquatic biota, the bioaccumulation factors are generally low and apparently nickel does generally not become magnified along food chains (McGeer et al. 2003). Some animal species seem to be able to regulate the nickel content of their tissues by controlled uptake and excretion / storage (Outridge and Scheuhammer 1993). An inverse relationship between the BCF and exposure concentration in water has been observed for certain aquatic organisms within the concentration range 1-100 ug/l (Brix and DeForest 2000, McGeer et al. 2003). This may support the hypothesis that within these concentration ranges active regulation of the uptake of nickel may take place (Muyssen et al. 2003).


In general, Ni bioaccumulation is relatively low. Bioconcentration factors were highest for the marine bivalve, Cerastoderme edule. For example, BCFs for C. edule were as high as 26,500, whereas the highest BCF for any other organism was 5,613 as reported for the cyanobacterium Anacystis nidulans. In general, BCFs for other bivalves were <340 (median = 270). This suggests that the BCFs observed for C. edule are not representative of other bivalves or aquatic organisms. A BCF of 1631 L/kg for C. edule was used in scenarios where this organism is a relevant prey item. For all other aquatic organisms, a calculated BCF value of 270 L/kg was used. For soil exposures, a BAF for earthworms of 0.3 was used.