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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No detail included in methodology and results. All studies included in the report are brief summaries.
Justification for type of information:
Supporting data only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No details on methodology included within study report.
GLP compliance:
not specified
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentapotassium triphosphate
EC Number:
237-574-9
EC Name:
Pentapotassium triphosphate
Cas Number:
13845-36-8
Molecular formula:
H5O10P3.5K
IUPAC Name:
pentapotassium triphosphate
Details on test material:
- Name of test material : potassium tripolyphosphate
- Analytical purity: No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
4640 mg/kg
No. of animals per sex per dose:
2 animals per dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
No data

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 4 640 mg/kg bw
Mortality:
No unscheduled deaths were recorded during the study
Clinical signs:
other: No signs of toxicity were noted. Moderate erythema and oedema were noted.
Gross pathology:
No data (not examined)
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Not specified Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 for potassium tripolyphosphate in rabbits was determined to be > 4640 mg/kg.