Registration Dossier
Registration Dossier
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EC number: 500-041-9 | CAS number: 25723-16-4 1 - 6.5 moles propoxylated
Endpoint summary
Administrative data
Description of key information
Additional information
The 96 hr LC50 to fish were reported as > 100 mg/l (nominal)(EU Method C1 , Danio rerio).
The 48 hr EC50 to aquatic invertebrates were reported as >100 mg/L(nominal) (Daphnia magna).
The 21d-NOEC to aquatic invertebrates is ≥ 8.5 mg/L (nominal) for all endpoints (nominal)(Daphnia magna).
72 hr ECr50 (Desmodesmus subspicatus) > = 100 mg/l.
72 hr NOEC (Desmodesmus subspicatus) > = 100 mg/l.
72 hr ECr50 (Pseudokirchnerella subcapitata) = 106 mg/l.
72 hr NOEC (Pseudokirchnerella subcapitata) = 31 mg/l.
3 hr (domestic sludge respiration rate inhibition) EC10 is >10,000 mgl/l . No inhibition of respiration was observed.
Read-across statement
No-Longer-Polymer (NLP) polyether polyols are produced by the reaction of various starter molecules with propylene oxide and/or ethylene oxide. These substances exhibit a remarkable uniformity in the physical/chemical properties which influence their fate and distribution in the environment. All NLP polyols have a full acute aquatic ecotoxicity dataset and do not exhibit acute toxicity below 100 mg/L. However, differentiation in chronic invertebrate toxicity is apparent and is based on the alcohol- or amino- starter molecules used to prepare these NLP polyols. A sub-grouping based on (i) aliphatic alcohol and amine NLP polyols, (ii) EDA- (ethylenediamine) based amino NLP polyols and (iii) o-TDA- (orthodiaminotoluene) based aromatic NLP polyols is justified (ISOPA, 2010) and toxicity is expected to be similar between substances within each of these categories. It is considered appropriate to use ‘read-across’ of data of structural analogues within each sub-grouping to fill data gaps for chronic invertebrate toxicity and derive PNECs for endpoints based on these sub-groupings.
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