Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-221-9 | CAS number: 4253-34-3
Endpoint summary
Administrative data
Description of key information
There are no repeated dose oral, inhalation or dermal studies available for methylsilanetriyl triacetate. Data waivers are in place for oral, inhalation and dermal repeated dose toxicity endpoints.
In a seven-day range-finding study conducted to determine appropriate doses for administration in an OECD TG 422 study with the related substance, ethylsilanetriyl triacetate (CAS 17689-77-9), a NOAEL could not be determined due to the corrosive effects of this substance on the oesophagus and stomach (DCC, 2004).
On the basis of this result and results of the skin corrosion studies, it is considered not to be either ethical or technically feasible to perform further repeat dose toxicity testing with methylsilanetriyl triacetate by any route of exposure at toxicologically relevant doses or concentrations due to its known corrosive properties.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
- System:
- gastrointestinal tract
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no repeated dose oral, inhalation or dermal studies available for methylsilanetriyl triacetate. Data waivers are in place for oral, inhalation and dermal repeated dose toxicity endpoints.
See attached data waiver justification and Section 5.6.3 of the Chemical Safety Report for further discussion.
Justification for classification or non-classification
The available data indicate that methylsilanetriyl triacetate does not need to be classified for specific target organ toxicity according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
