Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report Date:
1961

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
Saturated atmosphere estimated to be 690.4 ppm
No. of animals per sex per dose:
Three
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Remarks on result:
other: Not determined.

Any other information on results incl. tables

Animals were drowsy in 30 minutes. Bloody noses with laboured breathing observed upon removal from chamber. Some liver and kidney injury observed at autopsy. No further details.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
In an acute inhalation study (reliability score 4) 1/3 rats died following exposure to a saturated atmosphere (estimated to be 690.4 ppm) of methylsilanetriyl triacetate for 7 hours.