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EC number: 224-221-9 | CAS number: 4253-34-3
There are two separate rates for the elimination of 14CO2. The initial rate of elimination (1 to 8 hours postmedication) is very rapid and has a biological half-life of 4 to 6 hours, followed by a much slower rate of elimination (half-life of about 25 hours). The appearance of two separate rates of 14CO2elimination represents two routes of metabolism of the acetate carbons. The initial rate of elimination is probably due to the direct reaction of acetate with CoA-SH to form acetyl-CoA, which subsequently is oxidised to CO2through the TCA cycle. In the intact animal, the CO2would be present in the form of blood bicarbonate and as the blood bicarbonate is turned over, there is a subsequent release of CO2from the lungs. The slower, secondary rate of elimination is probably derived from acetate carbons which are incorporate into other metabolites, such as fatty acids and amino acids and are subsequently catabolised to CO2.
Adult white rats (5 to 9 months old) of an inbred Oregon State Wistar strain were used. The aqueous solutions of sodium acetate were administered to the rats by means of a stomach tube. After the acetate-C14was administered, the rat was placed in a Delmar metabolism cage and the CO2was trapped by sodium hydroxide solution. The sodium hydroxide solution from the CO2trap was changed periodically and was analyzed for radioactivity after conversion of CO2to BaCO3. The BaCO3was filtered onto a glass fiber disk, washed and dried and the radioactivity counted. The urine samples were collected and clarified by centrifugation at low speed. The radioactivity in the faeces was obtained by extracting the faeces with a sufficient volume of 50% ethanol. The solid materials were centrifuge out and an aliquot of the supernatant was analysed for radioactivity.
From 79 to 95% of orally administered acetate-14C was recovered in the form of 14CO2. Only a small amount of the radioactivity was found in the urine and faeces. The radioactivity recovered from excreta during the first 24-h period was considerably less from the males than from the females. Male rats apparently tend to fix more of the radioactivity in the body tissues, and the acetate carbons were not turned over as rapidly as in the females.
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