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Registration Dossier
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EC number: 201-605-4 | CAS number: 85-43-8
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Administrative data
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Additional information
Acute immobilisation to Daphnia magna has been investigated according to OECD/EU test methods. The effects of a limit concentration of 100 mg/L were determined, with and without adjustment of pH. The LC50 was in excess of 100 mg/L and the NOEC was 100 mg/L.
Algal growth inhibition to the unicellular freshwater green alga Pseudokirchneriella subcapitata has been investigated according to OECD/EU test methods. THPA was found to inhibit the growth after 72 hours exposure, EC50 values for inhibition of specific growth rate (ErC50) and yield (EyC50) being 65.3 mg/L and 61.4 mg/L, respectively. The potential for recovery from the observed effects was established.In accordance with ECHA guidance oninformation requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, theErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
Acute toxicity to fish (Rainbow trout) was determined according to OECD/EU test methods. A limit test was conducted under static conditions with a single concentration of 100 mg/L with and without adjustment of pH. The LC50 was in excess of 100 mg/L; the LOEC was 100 mg/L based on behavioural effects seen without adjustment of pH.
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