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EC number: 931-341-1 | CAS number: 68955-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27-09-1983 to 22-11-1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Amines, C12-18(even numbered)-alkyldimethyl, N-oxides
- EC Number:
- 931-341-1
- Cas Number:
- 68955-55-5
- Molecular formula:
- CnH(2n+3)NO, where n=14-20
- IUPAC Name:
- Amines, C12-18(even numbered)-alkyldimethyl, N-oxides
- Details on test material:
- - Name of test material: Hoe S 3406 (Alkyl-dimethyl-aminoxid)
- Physical state: Clear liquid
- Molecular weight: ca. 260.
- Lot/batch No.: E 06201846
- Storage condition of test material: In the dark at ca. 22 ºC.
- Other: Density ca 0.97 g/cm2 (20 ºC); pH value in water: 6 - 8 (1 % in distilled water); soluble in water.
Composition: 30 % alkylmethylaminoxid, 70 % water and impurities.
Impurities: Max. 0.3 % free fatty alcohol; max. 0.5 % free amine; max. 0.1 % H2O2.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoescht AG.
- Age at study initiation:
- Weight at study initiation: Males, mean = 202 g (191 - 219 g ); females, mean = 194 g (185 - 205 g)
- Fasting period before study: 16 h before and 2 h after application.
- Housing: Air-conditioned room in makrolon cages (type 4) on soft wood shavings in groups of 5 animals.
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 ºC
- Humidity (%): 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 12 h light/12 dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 % w/v
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg - Doses:
- 1250, 2000, 2500, 3150, 4000 and 5000 mg/kg bw.
- No. of animals per sex per dose:
- 5 females only for groups dosed at 1250, 2000 and 2500 mg/kg.
5/sex/dose for the group dosed at 3150 mg/kg.
5 males only for groups dosed at 4000 and 5000 mg/kg. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were weighed weekly
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs and body weight - Statistics:
- The LD50, the 95 % confidence range and the calculation of the probit were determined directly from the death rates (Probit analysis by the method of Lindner and Weber; the confidence limits were calculated according Fieller or Sidak).
Results and discussion
- Preliminary study:
- No data
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 120 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 400 - 5 010
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 820 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 360 - 3 540
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 236 mg/kg bw
- Based on:
- act. ingr.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 846 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- There were deaths in the female rats at 2500 mg/kg (1/5) and at 2500 mg/L (4/5).
Deaths in male rats occurred at 4000 mg/kg (3/5) and 5000 mg/kg (4/5).
Animals died at 1 - 2 days post exposure. - Clinical signs:
- other: After 10 minites after treatment male animals were observed squatting or prone on their stomach or side and a narrowing of the lids. After 30 - 60 miniutes these symptoms were also observed in the females. 30 -60 minutes post application diarrhoea was ob
- Gross pathology:
- The necropsy of the male animals that died during the study showed the stomach and small intestine filled with yellowish-green liquid and partial whitening of the liver was observed. The necropsy of the dead females showed a reddish liquid-filling the gastrointestinal tract. In two animals the thorax was filled with pink liquid. Some animals showed autolytic changes. Surviving animals were free from visible macroscopic changes.
- Other findings:
- No data
Any other information on results incl. tables
Clinical signs observed in females:
Time after application |
From |
0 min |
10 min |
30 min |
1 h |
2 h |
4 h |
1 d |
2 d |
3 d |
4 d |
To |
10 min |
30 min |
60 min |
2 h |
4 h |
6 h |
14 d |
||||
1250 mg/kg bw: Females |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
|
Number of animals with symptoms: |
|||||||||||
Ruffled fur |
|
|
|
5 |
5 |
5 |
|
|
|
|
|
No symptoms |
5 |
5 |
5 |
|
|
|
5 |
5 |
5 |
5 |
|
Necropsy: 5/5 no visible macroscopic abnormalities |
|||||||||||
2000 mg/kg bw: Females |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
|
Number of animals with symptoms: |
|||||||||||
Squatting |
|
|
2 |
2 |
2 |
2 |
|
|
|
|
|
Ruffled fur |
|
|
|
5 |
5 |
5 |
|
|
|
|
|
Subdued |
|
|
|
|
5 |
5 |
|
|
|
|
|
Diarrhoea |
|
|
|
5 |
5 |
5 |
|
|
|
|
|
No symptoms |
5 |
5 |
3 |
|
|
|
5 |
5 |
5 |
5 |
|
Necropsy: 5/5 no visible macroscopic abnormalities |
|||||||||||
2500 mg/kg bw: Females |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
1/5 |
1/5 |
1/5 |
1/5 |
|
Number of animals with symptoms: |
|||||||||||
Squatting |
|
2 |
3 |
5 |
3 |
5 |
|
|
|
|
|
Narrow palpebral fissures |
|
3 |
4 |
5 |
5 |
5 |
|
|
|
|
|
Positioned on their belly or side |
|
|
|
|
2 |
|
|
|
|
|
|
Belly and flanks drawn in |
|
|
2 |
3 |
5 |
3 |
|
|
|
|
|
Ruffled fur |
|
|
|
|
5 |
5 |
|
|
|
|
|
Diarrhoea |
|
|
2 |
3 |
5 |
5 |
|
|
|
|
|
No symptoms |
5 |
|
|
|
|
|
4 |
4 |
4 |
4 |
|
Necropsy: 1/5 gastrointestinal tract filled with yellow fluid 1/5 full bulging stomach 4/5 no visible macroscopic abnormalities |
|||||||||||
3150 mg/kg bw: Females |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
1/5 |
4/5 |
4/5 |
4/5 |
4/5 |
|
Number of animals with symptoms: |
|||||||||||
Squatting |
|
|
3 |
3 |
3 |
|
|
|
|
|
|
Ruffled fur |
|
|
|
5 |
5 |
|
|
|
|
|
|
Positioned on their belly or side |
|
|
|
2 |
2 |
3 |
|
|
|
|
|
Subdued |
|
|
|
5 |
5 |
4 |
|
|
|
|
|
Decreased respiratory rate |
|
|
|
|
2 |
4 |
|
|
|
|
|
Diarrhoea |
|
5 |
5 |
5 |
5 |
5 |
|
|
|
|
|
No symptoms |
5 |
|
|
|
|
|
1 |
1 |
1 |
1 |
|
Necropsy: 1/5 vessels of the gastrointestinal tract protruding 3/5 gastrointestinal tract filled with reddish fluid 2/5 thorax filled with pink fluid 1/5 gastrointestinal tract filled with yellow fluid 1/5 full bulging stomach 3/5 autolysis (advanced) 1/5 no visible macroscopic abnormalities |
Clinical signs observed in males:
Time after application |
From |
0 min |
10 min |
30 min |
1 h |
2 h |
4 h |
1 d |
2 d |
3 d |
4 d |
To |
10 min |
30 min |
60 min |
2 h |
4 h |
6 h |
14 d |
||||
3150 mg/kg bw: Males |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
|
Number of animals with symptoms: |
|||||||||||
Squatting |
|
4 |
2 |
2 |
1 |
1 |
|
|
|
|
|
Belly and flanks drawn in |
|
5 |
5 |
5 |
5 |
5 |
|
|
|
|
|
Subdued |
|
5 |
5 |
5 |
5 |
5 |
|
|
|
|
|
Positioned on their belly or side |
|
1 |
2 |
3 |
3 |
3 |
|
|
|
|
|
Decreased respiratory rate |
|
|
1 |
3 |
3 |
3 |
|
|
|
|
|
Ruffled fur |
|
|
5 |
5 |
5 |
5 |
|
|
|
|
|
High-legged position |
|
|
|
2 |
2 |
2 |
|
|
|
|
|
Narrow palpebral fissures |
|
|
|
4 |
5 |
5 |
|
|
|
|
|
Diarrhoea |
|
|
|
5 |
5 |
5 |
|
|
|
|
|
No symptoms |
5 |
|
|
|
|
|
5 |
5 |
5 |
5 |
|
Necropsy: 5/5 no visible macroscopic abnormalities |
|||||||||||
4000 mg/kg bw: Males |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
3/5 |
3/5 |
3/5 |
3/5 |
|
Number of animals with symptoms: |
|||||||||||
Subdued |
5 |
5 |
5 |
5 |
5 |
5 |
|
|
|
|
|
Narrow palpebral fissures |
|
5 |
5 |
3 |
5 |
5 |
|
|
|
|
|
Belly and flanks drawn in |
|
5 |
5 |
5 |
3 |
3 |
|
|
|
|
|
Creeping forward |
|
5 |
5 |
5 |
3 |
3 |
|
|
|
|
|
Decreased respiration rate |
|
|
2 |
2 |
3 |
3 |
|
|
|
|
|
Eyelids closed |
|
|
2 |
2 |
2 |
2 |
|
|
|
|
|
Supine position |
|
|
1 |
1 |
|
|
|
|
|
|
|
Squatting |
|
|
|
|
2 |
2 |
|
|
|
|
|
Diarrhoea |
|
|
3 |
5 |
5 |
5 |
|
|
|
|
|
Strong noisy breathing |
|
|
|
|
|
|
|
|
2 |
|
|
No symptoms |
|
|
|
|
|
|
2 |
2 |
|
2 |
|
Necropsy: 2/5 liver partially lightened 1/5 full bulging stomach 3/5 small intestine filled with yellowish-green liquid 3/5 autolysis (early stages) 2/5 no visible macroscopic abnormalities |
|||||||||||
5000 mg/kg bw: Males |
|||||||||||
Mortality |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
2/5 |
4/5 |
4/5 |
4/5 |
|
Number of animals with symptoms: |
|
|
|
|
|
|
|
|
|
|
|
Squatting |
|
|
|
|
|
|
|
|
|
|
|
Belly and flanks drawn in |
|
|
|
|
|
|
|
|
|
|
|
Subdued |
|
|
|
|
|
|
|
|
|
|
|
Supine position |
|
|
|
|
|
|
|
|
|
|
|
Eyelids closed |
|
|
|
|
|
|
|
|
|
|
|
Creeping forward |
|
|
|
|
|
|
|
|
|
|
|
Diarrhoea |
|
|
|
|
|
|
|
|
|
|
|
Ruffled fur |
|
|
|
|
|
|
|
|
|
|
|
Noisy breathing |
|
|
|
|
|
|
|
|
|
|
|
No symptoms |
|
|
|
|
|
|
|
|
|
|
|
Necropsy: 4/5 liver lightened 4/5 bulging translucent stomach 4/5 small intestine filled with yellowish green liquid 2/5 autolysis (early stages) 1/5 no visible macroscopic abnormalities |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity of the test substance was assessed in male and female rats according to OECD guideline 401 and EU method B.1. The acute oral LD50 of the test substance in males rats was 4120 mg/kg bw with 95 % confidence limits of 3400 - 5010 mg/kg bw. The acute oral LD50 of the test substance in female rats was 2820 mg/kg with 95 % confidence limits of 2360 - 3540 mg/kg bw.
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