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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The LC50 (96 h) for fish is 1.26 mg AO/L, based on the lowest LC50 derived from three reliable studies available. C12-18 AO and C12-14 AO exhibit similar acute toxicity to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1.26 mg/L

Additional information

Three reliable studies are available for C12-18 amine oxide. In the key study, performed according to OECD TG 203 under GLP [Rowlands (2005)] Rainbow trout (Oncorhynchus mykiss) were exposed to C12-18 AO under semi static conditions for 96 hours. The LC50 (96 h) was 1.26 mg AO/L, based on nominal concentrations. In a supporting study [Mark & Meuwsen (1990)] performed according to OECD TG 203 under GLP,Danio reriowere exposed to C12-18 AO under semi static conditions for 96 hours. The LC50 (96 h) based on nominal concentrations of amine oxide was 1.49 mg AO/L. In the third study [Hoechst (1977)] Golden orfe were exposed to C12-18 AO for 96 hours. The LC50 (96 h) was 4.32 mg AO/L based on nominal test concentrations.

There are four reliable studies available for the C12-14 amine oxide. Iwan GR et al (1975) exposed Fathead minnow (Pimephales promelas) to C12-14 AO under static conditions for 96 hours. The LC50 (96 h) based on nominal concentrations of amine oxide ranged from 2.67 to 3.46 mg AO/L depending on the source and pH of the water used. In a supporting study Bluegill (Lepomis macrochirus) were exposed to C12-14 AO under static conditions for 96 hours. The LC50 value was reported as 3.13 mg AO/L [Macek & Sleight (1972)]. Exposure of rainbow trout (Oncorhynchus mykiss) to C12-14 AO under static conditions for 96 hours resulted in a LC50 of 12.6 mg AO/L [Dommrose AM (1987)], whilst exposure of zebra fish (Danio rerio) to C12-14 AO under static conditions resulted in a 96 -h LC50 of 3 -30 mg AO/L [Hoechst AG (1987)].

Overall, it can be concluded that C12-18 AO and C12-14 AO exhibit similar acute toxicity to fish.