Registration Dossier
Registration Dossier
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EC number: 931-341-1 | CAS number: 68955-55-5
Endpoint summary
Administrative data
Description of key information
Additional information
C12-18 amine oxide and C12-14 amine oxide exhibit similar aquatic toxicity profiles. In some cases, particularly the chronic endpoints, the available studies for C12-14 AO are read across to C12-18 AO. This is justified on the basis of the large overlap in chain length distributions between the two substances, similarities in physico-chemical properties and the similar toxicity profiles.
Fish: Rowlands (2005) exposed Rainbow trout (Oncorhynchus mykiss) to C12-18 AO under semi static conditions for 96 hours in a GLP study performed according to OECD TG 203. The LC50 (96 h) was 1.26 mg AO/L, based on nominal concentrations.
No chronic study is available for C12-18 AO, but one is available for C12-14 AO. In a full life-cycle toxicity test (similar to EPA OPPTS 850.1500) fathead minnows (Pimephales promelas) were exposed to C12 -14 AO for 302 days under flow through conditions [Aquatic Environmental Services (1976)]. The NOEC was 0.42 mg AO/L (mean measured concentration), based on reduced fry survival, reduced egg hatch, and occluded eyes in test fish.
Daphnia: Noack (2001) exposed Daphnia magna to C12-18 AO under static conditions for 48 hours in a GLP study performed according to OECD TG202. The EC50 (48 h) was 2.4 mg AO/L.
No chronic study is available for C12-18 AO, but a 21-day survival and reproduction test with Daphnia magna following OECD TG 211 is available for C12-14 AO [Maki (1997)]. The 21 -day NOEC was 0.70 mg AO/L, based on both survival and reproduction.
Algae: One study is available for C12-18 AO. In this study [Scheerbaum D (2000) ] performed according to OECD TG 201 under GLP Desmodesmus subcapitata were exposed to C12-18 AO under static conditions for 72. The ErC50 (72 h) was 0.24 mg AO/L. Studies performed with C12-14 AO show Pseudokirchnerella subcapitata to be a more sensitive species, and the geometric mean 72 -h ErC50 for Pseudokirchnerella subcapitata is 0.143 mg AO/L (based on 4 studies).
The toxicity of C12-14 AO to algae was evaluated in a 28 -day freshwater periphyton microcosm assay [Belanger (1999)].The No-Observed Effect Concentration (NOEC) of the substance to the periphyton community was determined to be >67 ug AO/L, the highest test concentration evaluated (mean measured concentration).
Microorganisms: Kolvenbach (1990) exposed Pseudomonas putida to C12 -18 AO for 18 hours in a Bringmann-Kohn test. The EC10, based on reduction in growth rate, was 29.8 mg/L. In a similarly performed study using C12 -14 AO by the same author, the EC10 was 24 mg AO/L. This study is considered as the key study as the result is protective of C12 -18 AO.
Sediment-dwelling organisms: No studies are available, however risk characterisation using the equilibrium partitioning method indicates that the risk to sediment dwelling organisms is adequately controlled and there is no need for further refinement of the assessment through testing.
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