2,6-di-tert-butylphenol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1955

Report date:

1955

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

0.5 ml per kg 2,6-di-tert-butylphenol were applied to the skin of rabbits and direct contact maintained for 24h.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,6-di-tert-butylphenol

EC Number:

204-884-0

EC Name:

2,6-di-tert-butylphenol

Cas Number:

128-39-2

Molecular formula:

C14H22O

IUPAC Name:

2,6-di-tert-butylphenol

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

0.5 ml per kg

No. of animals per sex per dose:

10 rabbits (sex unknown)

Control animals:

no

Details on study design:

New Zealand rabbits ranging from 1.7 to 2.7 kg in body weight were used in these experiments. In preparation for the application of either of the compounds upon the skin of these animals, the hair was clipped as closely as possible from all areas of the trunk extending from the hips to the shoulders. A rubber sleeve, applied around the trunk in such manner as to fit snugly at its anterior and posterior edges but loosely in the intermediate area, covered the shorn skin of each rabbit. A measured amount of the specified compound was introduced beneath the sleeve and distributed in contact with as large an area of the bare skin as the dose would cover. The rubber sleeve was then covered completely with adhesive tape, and the animal was returned to its cage. After 24 hours had passed the sleeve was removed, and the skin was wiped as clean as possible with a dry towel.
Each of 10 rabbits was subjected in the manner described above, to contact of the skin with 2,6-di-tertiary butyl phenol in the dosage of 0.5 ml per kilogram.

Results and discussion

Preliminary study:

Each of 10 rabbits was subjected to contact of the skin with 2,6—di—tertiary butyl phenol in the dosage of 0.5 ml. per kilogram. These survived and exhibited no signs of illness and gained in weight at normal rates. Three animals developed a slight to moderate degree of erythema in the treated areas of the skin.

Effect levels

Sex:

not specified

Dose descriptor:

LD0

Effect level:

> 0.5 mL/kg bw

Remarks on result:

other: No signs of illness observed.

Mortality:

None

Clinical signs:

other: Three animals developed a slight to moderate degree of erythema in the treated areas of the skin.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Very low dermal toxicity and slightly irritating.

Executive summary:

Each of 10 rabbits was subjected to contact of the skin with 2,6-di-tertiary butyl phenol in the dosage of 0.5 ml. per kilogram. These survived and exhibited no signs of illness and gained in weight at normal rates. Three animals developed a slight to moderate degree of erythema in the treated areas of the skin.