Registration Dossier
Registration Dossier
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EC number: 237-159-2 | CAS number: 13674-87-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Data for the oral route of exposure is not quantifiable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Objective of study:
- absorption
- distribution
- Principles of method if other than guideline:
- Fyrol FR-2 was administered by oral intubation at 3 different concentrations, following administration, the animals were held in individual metabolism.
- GLP compliance:
- no
Test material
- Details on test material:
- - Test substance purity not stated
- Radioactively labelled TDCP ([1,3-(14)C]2-propyl, specific activity 12.5mCi/mmol, radiochemical purity >99%)
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- carbon -14
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: NIEHS breeding colony
- Weight at study initiation: 150-200 g
- Individual metabolism cages: yes
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Emulphor:ethanol:water (1:1:8)
- Duration and frequency of treatment / exposure:
- Duration appears to be 24h, treatment is once-off
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2, 2 and 20 umol/kg (corresponding to 86ug/kg, 860ug/kg and 8.6mg/kg)
- No. of animals per sex per dose / concentration:
- At least three rats per dose
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Absorption from the GI tract was >90% within 24h (the report does not detail how this was measured)
- Details on distribution in tissues:
- After 24h the pattern of distribution is Kidney > Liver > Lung > Blood > Muscle.
- Details on excretion:
- No information was provided on excretion.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Applicant's summary and conclusion
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