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EC number: 248-227-6 | CAS number: 27107-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 8th August - 11th September 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Octyltin tris(2-EHMA) [CAS No. 27107-89-7]:Dioctyltin bis(2-EHMA) [CAS No. 15571-58-1] (67%:33% mixture); liquid, >=96 wt% purity
- IUPAC Name:
- Octyltin tris(2-EHMA) [CAS No. 27107-89-7]:Dioctyltin bis(2-EHMA) [CAS No. 15571-58-1] (67%:33% mixture); liquid, >=96 wt% purity
- Details on test material:
- Octyltin tris(2-EHMA) [CAS No. 27107-89-7]:Dioctyltin bis(2-EHMA) [CAS No. 15571-58-1] (67%:33% mixture); liquid,
>=96 wt% purity,
Constituent 1
Method
- Target gene:
- S. typhimurium: histidine locus
E. coli: tryptophan locus
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- N/A
- Species / strain / cell type:
- S. typhimurium TA 1538
- Details on mammalian cell type (if applicable):
- N/A
- Species / strain / cell type:
- E. coli WP2 uvr A
- Details on mammalian cell type (if applicable):
- N/A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 fraction of rat livers
- Test concentrations with justification for top dose:
- 5, 10, 50, 100, 500, 1000, 5000 µg/0.1 ml
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: Acetone for test substance, DMSO for positve controls
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Acetone
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: see remarks section.
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in medium; in agar (plate incorporation)
DURATION
- Preincubation period: NDA
- Exposure duration: 48 hours
- Expression time (cells in growth medium): NDA
- Selection time (if incubation with a selection agent): NDA
- Fixation time (start of exposure up to fixation or harvest of cells): NDA
SELECTION AGENT (mutation assays): NDA
SPINDLE INHIBITOR (cytogenetic assays): NDA
STAIN (for cytogenetic assays): NDA
NUMBER OF REPLICATIONS: 3
NUMBER OF CELLS EVALUATED: NDA
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- These tests permit the detection of point mutations in bacteria induced by chemical substances. Any mutagenic effects of the substances are demonstrable on comparison of the number of bacteria in the treated and control cultures that have undergone back-mutation to histidine- or tryptophan-prototrophism. To ensure that mutagenic effects of metabolites of the test substance formed in mammals would also be detected, experiments were performed in which the cultures were additionally treated with an activation . mixture (rat liver microsomes and co-factors)
- Statistics:
- no
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- NDA
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 1. Results of tests - mean colony counts.
Material | Concentration of testing sample (µg/plate) | Presence of S9 mix | Back mutation - Number of colonies/plate (mean) | |||||
Base conversion type | Frame shift type | |||||||
TA100 | TA1535 | WP2UVrA | TA98 | TA1537 | TA1538 | |||
Vehicle control | N/A | - | 148 | 15 | 22 | 22 | 6 | 12 |
TK 12152 | 5 | - | 133 | 13 | 25 | 25 | 5 | 6 |
10 | - | 136 | 12 | 26 | 17 | 5 | 12 | |
50 | - | 134 | 17 | 21 | 23 | 7 | 17 | |
100 | - | 139 | 15 | 18 | 25 | 6 | 12 | |
500 | - | 122 | 11 | 17 | 20 | 5 | 15 | |
1000 | - | 132 | 13 | 23 | 16 | 5 | 11 | |
5000 | - | 117 | 15 | 23 | 16 | 8 | 8 | |
Vehicle control | N/A | + | 132 | 14 | 23 | 34 | 5 | 54 |
TK 12152 | 5 | + | 116 | 8 | 22 | 45 | 11 | 53 |
10 | + | 135 | 7 | 22 | 40 | 7 | 50 | |
50 | + | 128 | 7 | 28 | 36 | 8 | 55 | |
100 | + | 122 | 11 | 29 | 41 | 8 | 43 | |
500 | + | 138 | 9 | 21 | 39 | 6 | 40 | |
1000 | + | 107 | 10 | 23 | 33 | 5 | 38 | |
5000 | + | 110 | 8 | 26 | 27 | 4 | 24 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In the experiments performed without and with microsomal activation, comparison of the number of back-mutant colonies in the controls and the cultures treated with the various concentrations of TK 12 152 (Octyltin tris(2-ethylhexylmercaptoacetate) revealed no marked deviations.
No evidence of the induction of point mutations by TK 12 152 or by the metabolites of the substance' formed as a result of microsomal activation was detectable in the strains of S. typhimurium and E. coli used in these experiments. - Executive summary:
TK 12 152 (Octyltin tris(2-ethylhexylmercaptoacetate) was tested for mutagenic effects on histidine-auxotrophic strains of Salmonella typhimurium and on a tryptophan auxotrophic strain of E. coll. The investigations were performed with the following concentrations of the trial substance without and with microsomal activation: 5, 10, 50, 100, 500, 1000 and 5000 µg/0.l ml.
In the experiments performed without and with microsomal activation, comparison of the number of back-mutant colonies in the controls and the cultures treated with the various concentrations of TK 12 152 (Octyltin tris(2-ethylhexylmercaptoacetate) (MOTE) revealed no marked deviations.
No evidence of the induction of point mutations by TK 12 152 or by the metabolites of the substance' formed as a result of microsomal activation was detectable in the strains of S. typhimurium and E. coli used in these experiments.
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