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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
According to Annex XI section 2 of the Regulation EC 1907/2006; testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance. Specifically, a study according to OECD 106 is not considered to be technically feasible since this method is only suitable for substances for which an analytical method with sufficient accurancy is available. Additionally, the guideline notes that difficulties may arise in conducting this test for test substances with low water solubility. A QSAR calculated the water solubility of the substance to be 1.907 E-12 mg/L. For these reasons, conducting a study according to OECD 106 is not considered to be technically feasible. Similarly, it is not considered to be possible to conduct a study according to OECD 121 as this method is only suitable for substances with a Log Koc value between 1.5 and 5.0. A QSAR caluclation suggests that the Log Koc of the substance is 8.77 (Kow Method) or 10.11 (MCI Method). Both values are significantly above 5.0. For these reasons it is not considered to be technically feasible to conduct an adsorption/ desoprtion screening study with the substance.

Description of key information

According to Annex XI section 2 of the Regulation EC 1907/2006; testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance. Specifically, a study according to OECD 106 is not considered to be technically feasible since this method is only suitable for substances for which an analytical method with sufficient accurancy is available. Additionally, the guideline notes that difficulties may arise in conducting this test for test substances with low water solubility. A QSAR calculated the water solubility of the substance to be 1.907 E-12 mg/L. For these reasons, conducting a study according to OECD 106 is not considered to be technically feasible. Similarly, it is not considered to be possible to conduct a study according to OECD 121 as this method is only suitable for substances with a Log Koc value between 1.5 and 5.0. A QSAR caluclation suggests that the Log Koc of the substance is 8.77 (Kow Method) or 10.11 (MCI Method). Both values are significantly above 5.0. For these reasons it is not considered to be technically feasible to conduct an adsorption/ desoprtion screening study with the substance.

Key value for chemical safety assessment

Additional information