Registration Dossier
Registration Dossier
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EC number: 202-855-7 | CAS number: 100-47-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 May - 19 June, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.5
- Temp.:
- 20 °C
- pH:
- 7.4
- Remarks on result:
- other: pH of the water phases and the saturated buffer solutions.
- Type:
- Pow
- Partition coefficient:
- 35
- Temp.:
- 20 °C
- pH:
- 7.4
- Remarks on result:
- other: pH of the water phases and the saturated buffer solutions.
- Conclusions:
- The partition coefficient (n-octanol/water) for Benzonitrile was determined to be 35 (log Pow = 1.5) at 20 +/- 0.5 °C.
- Executive summary:
This GLP study was carried out in accordance with the OECD guideline for testing of chemicals number 107 (May 1981) and the EC method A.8, Official Journal of the European Communitites 92/69/EEC, No L 383 (Dec. 1992) with the shake flask method. The octanol/water partition coefficient (Pow) and its logarithm to base 10 (log Pow) were determined to be:
Pow = 35 at 20 +/- 0.5 °C
log Pow = 1.5 at 20 +/- 0.5 °C
Reference
Description of key information
The partition coefficient (n-octanol/water) for Benzonitrile was determined to be 35 (log Pow = 1.5) at 20 +/- 0.5 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.5
- at the temperature of:
- 20 °C
Additional information
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