Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Screening test. 5 animals only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956

Materials and methods

Principles of method if other than guideline:
Screening test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
polyethylene glycol
Duration of treatment / exposure:
4 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
200 mg/kg
Control animals:
other: no data specified
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Scabs developed at the injection sites but there were no
systemic effects. A post mortem examination revealed nothing
abnormal. Histological examination of the major organs
revealed no signs of any pathological changes.

Applicant's summary and conclusion