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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Screening-test. Only very short summary available. Only one dose, only one sex, only 3 animals.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1970
Reference Type:
study report
Title:
Unnamed
Year:
1956

Materials and methods

Principles of method if other than guideline:
Screening-test
GLP compliance:
no
Test type:
other: subacute
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
air
Duration of exposure:
6 - 7 h
Remarks on duration:
subacute study: 13 x daily; 5 days a week
Concentrations:
1 mg/L (120 ppm)
No. of animals per sex per dose:
3
Control animals:
not specified
Details on study design:
Post-exposure period: no, Animals were killed at the end of exposure period.
Three rats were exposed to air which had been bubbeled through the test substance. From the measured loss in weight of the liquid the atmospheric concentration was calculated.

Results and discussion

Preliminary study:
The animals became somewhat lethargic during the exposures but no definite symptomes developed. Normal weight gain. The post mortem examination showed some discolouration of the lungs. A histological examination of the lungs showed some thickening of the alveolar walls with a lymphocytic reaction around the bronchioles. The other major organs showed no signs of patological changes.
Effect levels
Sex:
female
Dose descriptor:
LCLo
Effect level:
> 1 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: 1 mg/L corresponds to 120 ppm; exposure 6 or 7 hrs/d; screening test performed for 13 days
Mortality:
No mortality.
Body weight:
Normal weight gain.
Gross pathology:
The other major organs showed no signs of patological changes.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met