Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Effect of several resin monomers on water insoluble glucan formation by Glucosyltrans- ferase of Streptococus sobrinus.
Author:
Kawai K, Torii M, Tsuchitani Y
Year:
1989
Bibliographic source:
J. Osaka Univ. Dent. Sch. 29: 65-71

Materials and methods

Type of study / information:
Type: Plaque accumulation
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

EGDMA and eluate from EGDMA-based experimental composite showed a tendency of inhibiting GTase and the eluate from experimental resin decreased the production of WIG. The authors conclude that
EGDMA used as a diluent monomer inhibits the GTase activity and would therefore result in decreased adherence of S.
mutans and dental caries.

Applicant's summary and conclusion