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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: case report
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
publication
Title:
Burning mouth syndrome: A possible etiologic role for local contact hypersensitivity
Author:
Dutrée-Meulenberg R.O.G.M., Kozel M.M.A., Van Joost Th.
Year:
1992
Bibliographic source:
Journal of the American Academy of Dermatology 26: 935 - 940

Materials and methods

Type of study / information:
human - skin sensitization, case reports
Endpoint addressed:
skin sensitisation
Test guideline
Qualifier:
no guideline available

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Details on study design:
22 patients (19 women and 3 men) classified with the burning mouth syndrome (BMS) were patch tested with a standard routine series and a 
standardized denture-dental ((meth)acrylate and metal) series. 

Results and discussion

Results:
Twenty of the 22 patients wore a complete or partial denture. None of the 22 patients showed a positive reaction to the tested methacrylates
(Methyl methacrylate, Ethyl methacrylate, 2-Hydroxyethyl methacrylate, 2-Hydroxypropyl methacrylate, Ethylene glycol dimethacrylate 2 % in pet.).

Applicant's summary and conclusion